Mike Bradburn
MSc
School of Medicine and Population Health
Senior Medical Statistician
+44 114 222 0706
Full contact details
School of Medicine and Population Health
Barber House
Sheffield
S10 2HQ
- Profile
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I joined Sheffield Clinical Trials Research Unit in 2007, having previously worked as a statistician at Cancer Research UK and PAREXEL International. In my current role I oversee the statistical input and conduct of the CTRU's portfolio of clinical studies, advise researchers via the NIHR's Research Support Service, and supervising University postgraduate students.
- Research interests
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My role primarily involves me working with researchers to design and conduct clinical studies. My methodological interests are survival analysis, meta-analysis and the generalisability of clinical trials to wider populations.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- . Journal of Clinical Epidemiology, 124, 126-138.
- . Journal of Clinical Epidemiology, 92, 116-125.
- . Lancet, 389(10068), 538-546.
- . Lancet, 388(10042), 356-364.
- . Lancet Neurology, 14(9), 883-892.
- . Stat Med, 26(1), 53-77.
All publications
Journal articles
- . Oral Diseases.
- . BMC Anesthesiology.
- . Health Technol Assess, 29(51), 1-28.
- . Journal of Geriatric Oncology, 16(7).
- . BMJ Open, 15(5).
- . Journal of Geriatric Oncology, 16(4), 102226-102226.
- . BJA Open, 13.
- . Colorectal Disease, 27(1).
- . Colorectal Disease, 27(1).
- . The Cognitive Behaviour Therapist, 17.
- . Health Technology Assessment, 28(33).
- . The Lancet.
- . European Journal of Neurology, 31(8).
- . British Journal of Surgery, 111(3).
- . Health Technology Assessment, 28(16), 1-93.
- . Efficacy and Mechanism Evaluation, 11(3).
- . Clinical Oncology, 36(5), 318-334.
- . Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 25(3-4), 290-298.
- . The Lancet Gastroenterology and Hepatology.
- . Clinical Trials, 21(1), 85-94.
- . British Journal of Anaesthesia, 132(1), 76-85.
- . British Journal of Cancer, 129(10), 1599-1607.
- . Emergency Medicine Journal, 40(11), 768-776.
- . Obstetric Anesthesia Digest, 43(3), 152-153.
- . Pilot and Feasibility Studies, 9.
- . BMJ Open, 13(2).
- . The Lancet, 401(10372), 192-193.
- . Colorectal Disease, 25(5), 984-994.
- . Annals of The Royal College of Surgeons of England, 105(5), 413-421.
- . Techniques in Coloproctology, 27(2), 117-124.
- . Heart, 109(3), 223-231.
- . BMC Neurology, 22(1).
- . The Lancet, 400(10363), 1597-1606.
- . Health Technology Assessment, 26(39).
- . The Lancet, 400(10353), 680-690.
- . British Journal of Anaesthesia, 129(4), 567-580.
- . Programme Grants for Applied Research, 10(6), 1-114.
- . Health Technology Assessment, 26(28).
- . Modern Pathology, 35, 1151-1159.
- . JAMA Network Open, 5(1).
- . Health Science Reports, 4(4).
- . Radiotherapy and Oncology, 161, 166-176.
- . Trials, 22(1).
- . Chest, 160(6), 2061-2065.
- . The Lancet Psychiatry, 8(6), 487-499.
- . Pituitary, 24(5), 724-736.
- . British Journal of Cancer, 125(2), 209-219.
- . Value in Health, 24(6), 770-779.
- . Journal of Human Nutrition and Dietetics, 34(6), 1064-1071.
- . Colorectal Disease, 23(6), 1487-1498.
- . British Journal of Surgery, 108(3), 315-325.
- . British Journal of Surgery, 108(5), 499-510.
- . Health Technology Assessment, 25(7).
- . European Journal of Cancer, 144, 269-280.
- . Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 22(5-6), 350-359.
- . Colorectal Disease, 23(1), 307-315.
- . BMC Emergency Medicine, 21.
- . PLoS ONE, 16(1).
- . European Journal of Cancer, 142, 48-62.
- . Journal of Geriatric Oncology, 12(5), 705-713.
- . Journal of Geriatric Oncology, 12(5), 714-723.
- . British Paramedic Journal, 5(3), 15-22.
- . Journal of Clinical Epidemiology, 124, 126-138.
- . BMJ Open, 10(7).
- . The Lancet Child and Adolescent Health, 4(2), 131-140.
- . Trials, 21.
- . Archives of Disease in Childhood - Fetal and Neonatal Edition, 105(1), 109-110.
- . BMJ Open, 9(7).
- . European Journal of Surgical Oncology, 45(12), 2319-2324.
- . BMC Gastroenterology, 19(1).
- . BMC Psychiatry, 19(1).
- . Trials, 20(1).
- . British Journal of Health Psychology, 24(4), 953-969.
- . BMJ Open, 9.
- . BMJ Open, 9(10).
- . Health Technology Assessment, 23(49), 1-144.
- . Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 20(7-8), 521-531.
- . Clinical Radiology, 74(7), 527-533.
- . Journal of Surgical Research, 238, 23-28.
- . BJS Open, 3(3), 354-366.
- . BJOG: An International Journal of Obstetrics and Gynaecology, 126(3), 383-392.
- . European Radiology, 29(1), 195-201.
- . British Journal of Psychiatry, 214(2), 63-73.
- . Pilot and Feasibility Studies, 4.
- . Trials, 19.
- . Osteoporosis International, 29(6), 1407-1417.
- . BMJ Open, 8.
- . Journal of Neurology, Neurosurgery and Psychiatry, 89, 248-255.
- . Clinical Radiology, 73(2), 123-134.
- . Ultrasound in Obstetrics and Gynecology, 50(6), 745-752.
- . Ultrasound in Obstetrics & Gynecology, 50(6), 736-744.
- . Journal of Clinical Epidemiology, 92, 116-125.
- . BMJ Open, 7(10).
- . Obstetrical & Gynecological Survey, 72(6), 323-325.
- . Clinical Radiology, 72(6), 451-457.
- . Trials, 18.
- . PharmacoEconomics Open.
- . Ultrasound in Obstetrics & Gynecology, 50(6), 753-760.
- . BMJ, 356.
- . RMD Open, 3(1).
- . Trials, 18(1), 93.
- . Lancet, 389(10068), 538-546.
- . European Radiology.
- . Cochrane Database of Systematic Reviews, 2016(12).
- . Health Technology Assessment, 20(88), 1-150.
- . Health Technology Assessment, 20(93), 1-154.
- . Health Technology Assessment, 20(90).
- . Lancet, 388(10042), 356-364.
- . Health Technology Assessment, 20(45), 1-186.
- . European Journal of Neurology, 23(6), 1071-1078.
- . Diabetic Medicine, 33(2), 243-251.
- . BMC Pulmonary Medicine, 15.
- . Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 16(7-8), 448-455.
- . Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 23.
- . Lancet Neurology, 14(9), 883-892.
- . Health Technology Assessment, 19(66).
- . Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 16(7-8), 478-484.
- . Journal of Clinical Epidemiology, 68(3), 347-354.
- . Health Services and Delivery Research, 3(1), 1-180.
- . Clinical Radiology, 70(3), 248-253.
- . Thorax, 69(12), 1105-1112.
- . The Journal of Clinical Endocrinology & Metabolism, 99(12), 4462-4470.
- . BMC Psychiatry, 14, 5.
- . Diabetes Research and Clinical Practice, 106(3), 443-450.
- . Emerg Med J, 31(e1), e40-e45.
- . Health Technol Assess, 18(22), 1-168.
- . BMC Psychiatry, 13, 321.
- . J Foot Ankle Res, 6(1), 40.
- . Trials, 14(1).
- . Lancet Respiratory Medicine, 1(4), 293-300.
- . Eur J Prev Cardiol, 20(1), 107-120.
- . J Bone Miner Res, 27(11), 2314-2324.
- . BMC Gastroenterol, 12, 153.
- . BMC Neurol, 12, 74.
- . Amyotroph Lateral Scler, 13(6), 528-532.
- . Health and Social Care in the Community, 20(5), 537-549.
- . Osteoporosis International, 1-14.
- . Health Qual Life Outcomes, 10, 20.
- . Heart, 98(4), 312-318.
- . Heart, 98(4), 312-318.
- . Emergency Medicine Journal, 29(3), 233-238.
- . Am J Emerg Med, 30(1), 37-44.
- . Emerg Med J, 29(1), 47-53.
- . Acad Emerg Med, 18(5), 488-495.
- . Archives of Disease in Childhood, 96(7), 658-663.
- . Osteoporosis International, 22(10), 2721-2731.
- . Heart, 97(3), 190-196.
- . Br J Clin Psychol, 49(Pt 4), 473-489.
- Looking inside the black box of community rehabilitation and intermediate care teams in the United Kingdom: an audit of service and staffing.. Qual Prim Care, 17(5), 323-333.
- metan: fixed- and random-effects meta-analysis. STATA J, 8(1), 3-28.
- . International Journal of Therapy and Rehabilitation, 15(9), 374-375.
- . Stat Med, 26(1), 53-77.
- Indirect comparisons of competing interventions. HEALTH TECHNOL ASSES, 9(26), 1-+.
- . Br J Haematol, 129(6), 746-754.
- . BRIT J HAEMATOL, 129(1), 35-44.
- . PATIENT EDUC COUNS, 58(1), 13-26.
- . Blood, 104(11), 165-165.
- . Nicotine Tob Res, 6(5), 769-776.
- . CANCER, 100(10), 2148-2153.
- . Studies in Health Technology and Informatics, 107, 197-201.
- . Breast Cancer Research, 5(6), R242-R249.
- Do men and women differ in response to nicotine replacement therapy: A meta-analysis. NICOTINE TOB RES, 5(5), 787-788.
- . Br J Cancer, 89(5), 781-786.
- . Br J Cancer, 89(4), 605-611.
- . Br J Cancer, 89(3), 431-436.
- . Br J Cancer, 89(2), 232-238.
- . Hematology, 6(3), 163-175.
- Reducing community dyspepsia drug costs: a controlled trial. GUT, 49(4), 495-501.
- Subcellular localisation of cyclin B, Cdc2 and p21(WAF1/CIP1) in breast cancer: association with prognosis. EUR J CANCER, 37(18), 2405-2412.
- Teaching non-specialist health care professionals how to identify the atypical mole syndrome phenotype: a multinational study. BRIT J DERMATOL, 142(2), 331-337.
- . Br J Haematol, 108(2), 455-457.
- High-dose treatment with autologous bone marrow support as consolidation of first remission in younger patients with acute myelogenous leukaemia. ANN ONCOL, 11(8), 1007-1015.
- Overexpression of H-Ryk in epithelial ovarian cancer: Prognostic significance of receptor expression. CLIN CANCER RES, 6(8), 3271-3281.
- High-dose therapy with autologous bone marrow support as consolidation of remission in follicular lymphoma: Long-term clinical and molecular follow-up. J CLIN ONCOL, 18(3), 527-536.
- Patterns of outcome following recurrence after myeloablative therapy with autologous bone marrow transplantation for follicular lymphoma. J CLIN ONCOL, 17(1), 216-221.
- Immunocytoma: A retrospective analysis from St Bartholomew's Hospital - 1972 to 1996. J CLIN ONCOL, 17(9), 2847-2853.
- . The Journal of Urology, 1932-1932.
- . Journal of Urology, 160(5), 1932-1932.
- . BMJ, 317(7165), 1041-1046.
- Detection of residual disease following breast-conserving surgery. BRIT J SURG, 85(9), 1273-1276.
- . Br J Cancer, 77(11), 1944-1949.
- Vascular endothelial growth factor is a predictor of relapse and stage progression in superficial bladder cancer.. Cancer Res, 57(23), 5281-5285.
- . BMC Geriatrics.
- . Pilot and Feasibility Studies, 4(1).
- . The Hematology Journal, 3(5), 237-243.
- . The Hematology Journal, 1(6), 367-373.
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Book chapters
- Sweetening the pill: Compliance and clinical trials In Davies M & Kermani F (Ed.), Patient Compliance: Sweetening the Pill (pp. 109-132). Gower Publishing Ltd
- In Egger M, Smith GD & Altman DG (Ed.), Systematic Reviews in Health Care (pp. 347-372). Wiley-Blackwell
- In Egger M, Smith GD & Altman DG (Ed.), Systematic Reviews in Health Care: Meta-Analysis in Context (pp. 285-312). Wiley-Blackwell
Conference proceedings
- . Value in Health, Vol. 25(12). Vienna, 6 November 2022 - 6 November 2022.
- . Clinical Nutrition ESPEN, Vol. 48 (pp 510-510). Brighton, UK, 30 November 2021 - 30 November 2021.
- . Annals of Oncology, Vol. 31 (pp S318-S319)
- . Cancer Research, Vol. 80(4_Supplement)
- Bridging the age gap in breast cancer: optimisation of survival and quality of life outcomes in older women with early breast cancer. BREAST CANCER RESEARCH AND TREATMENT, Vol. 180(2) (pp 594-594)
- . British Paramedic Journal, Vol. 4(3) (pp 53-54). Cardiff, Wales, 24 September 2019 - 24 September 2019.
- . Trials, Vol. 20(Suppl 1) (pp 53-54). Brighton, UK, 6 October 2019 - 9 October 2019.
- . Trials, Vol. 20(Supplement 1) (pp 124-124). Brighton, UK, 6 October 2019 - 6 October 2019.
- . Clinical Nutrition ESPEN, Vol. 29 (pp 265-266)
- . Journal of the Neurological Sciences , Vol. 381s (pp 102-102). Kyoto, Japan, 16 September 2017 - 16 September 2017.
- . Harnessing the Power of Technology to Improve Lives, Vol. 242 (pp 152-159). Sheffield, UK, 13 September 2017 - 13 September 2017.
- ULTRASOUND COMPARED WITH BIOPSY IN THE DIAGNOSIS OF SUSPECTED GIANT CELL ARTERITIS. RHEUMATOLOGY, Vol. 55 (pp 37-37)
- INTERRATER AND INTRARATER ANALYSIS OF ULTRASOUND AND HISTOLOGICAL FINDINGS IN PATIENTS WITH SUSPECTED GIANT CELL ARTERITIS. RHEUMATOLOGY, Vol. 55 (pp 171-171)
- Elevated creatine kinase is associated with a better prognosis in patients with amyotrophic lateral sclerosis. Neurology, Vol. 22 (pp 741-741). Washington D.C., 18 April 2015 - 18 April 2015.
- . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 85(10) (pp e4.93-e4)
- . Neurology, Vol. 82(10_supplement)
- Late-breaking abstract: Hypertonic saline in acute bronchiolitis: Randomised controlled trial (RCT) and economic evaluation (the SABRE study). EUROPEAN RESPIRATORY JOURNAL, Vol. 44
- . J Neurol Neurosurg Psychiatry, Vol. 84(11) (pp e2). England
- . J Neurol Neurosurg Psychiatry, Vol. 84(11) (pp e2). England
- . Trials, Vol. 12 Suppl 1 (pp A26)
- (YOUNG INVESTIGATOR AWARD) HIP STRUCTURE ANALYSIS OF HIP QCT SCANS AND HIP FRACTURE RISK IN OLDER MEN. OSTEOPOROSIS INTERNATIONAL, Vol. 21 (pp S455-S455)
- The RATPAC Trial (Randomised Assessment of Treatment using Panel Assay of Cardiac markers): a randomised controlled trial of point-of-care cardiac markers in the emergency department. EUROPEAN HEART JOURNAL, Vol. 31 (pp 947-947)
- Early response to induction is predictive of survival in childhood Philadelphia chromosome positive acute lymphoblastic leukaemia: Results of the Medical Research Council ALL 97 trial.. BLOOD, Vol. 104(11) (pp 51A-51A)
- Outcome of Philadelphia positive (Ph+) childhood acute lymphoblastic leukaemia (ALL) on the MRC ALL 97/01 trial. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 125 (pp 1-1)
- Genetic risk factor for follicular lymphoma within the MHC region.. BLOOD, Vol. 100(11) (pp 567A-567A)
- . Annals of Oncology, Vol. 11 (pp S117-S121)
- Treatment of mantle-cell lymphoma with Rituximab (chimeric monoclonal anti-CD20 antibody): Analysis of factors associated with response. ANNALS OF ONCOLOGY, Vol. 11 (pp 117-121)
- An analysis of factors which predict failure to mobilize peripheral blood progenitor cells (PBPC) with G-CSF alone in patients with non-Hodgkion's lymphoma.. BRIT J CANCER, Vol. 80 (pp 64-64)
- . Rheumatology
Reports
Posters
- Lessons learnt from a multi-centre type 3 surgical trial. 5th International Clinical Trials Methodology Conference (ICTMC 2019).
- Challenges in the design, planning and implementation of trials evaluating group interventions. 5th International Clinical Trials Methodology Conference (ICTMC 2019).
- ePS5.05 Understanding objective adherence to preventative inhaled therapies at a centre level for quality improvement - a CFHealthHub (CFHH) improvement collaborative study.
- #20 Design and rationale of the PIlonidal sinus Treatment - STudying the OPtions (PITSTOP) study: a multicentre cohort, nested mixed-methods case study and discrete choice experiment (poster presentation).
Other
- . The Lancet, 388(10063), 2996-2996.
- . The Lancet Neurology, 15(6), 543-544.
- . Osteoporosis International, 22(10), 2733.
- . NICOTINE TOB RES, 6(5), 865-867.
- Randomised trials useful to find best methods of enhancing clinical practice. BRIT MED J, 318(7194), 1353-1353.
Preprints
- , Springer Science and Business Media LLC.
- , Springer Science and Business Media LLC.
- , Cold Spring Harbor Laboratory.
- , Springer Science and Business Media LLC.
- , Springer Science and Business Media LLC.
- , Springer Science and Business Media LLC.
- Research group
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Clinical Trials Research Unit
- Grants
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I am a co-applicant on five ongoing NIHR-funded trials:
- Contact-GAD - A randomised CONtrolled trial of Tailored Acceptance and Commitment Therapy for older people with treatment resistant Generalised Anxiety Disorder
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- ORION - RadiO fRequency ablatION for haemorrhoids
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In addition, I am a co-applicant on two studies funded by the Yorkshire Cancer Research Pioneer fund:
E-IMMUNE - Empowerment of patients and clinicians in the management of immunotherapy toxicity through a new digital care pathway
EVIDENT - The Ex-VIvo DEtermined caNcer therapy study
- Professional activities and memberships
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I'm a member of the review panel for the NIHR HTA's Commissioned Calls funding stream, and of the statistical methods subcommittee within the Trials and Methodology Research Partnership programme. Previously I've been a committee member for the UKCRC CTU network statistics operations group.