Professor Matt Hammond

BSc, BA, MSc

School of Medicine and Population Health

Director of the Sheffield Clinical Trials Research Unit

Professor of Clinical Trials

Matt Hammond
Profile picture of Matt Hammond
matthew.hammond@sheffield.ac.uk
Barber House

Full contact details

Professor Matt Hammond
School of Medicine and Population Health
Barber House
Sheffield
S10 2HQ
Profile

Professor Matt Hammond is Director of the Sheffield Clinical Trials Research Unit (CTRU) within the School of Medicine and Population Health at the TV. He is an experienced clinical trials methodologist and senior research leader with over 20 years’ experience working in UKCRC-registered Clinical Trials Units, delivering high-quality multicentre clinical research across a wide range of clinical areas.

Professor Hammond’s expertise spans the full clinical trial lifecycle, including the design, governance, and delivery of CTIMPs, investigational medicinal device studies, and complex intervention trials, from early-phase studies through to large pragmatic randomised controlled trials. Prior to his appointment in Sheffield, he held senior leadership roles at Norwich Clinical Trials Unit, including Deputy Director and Interim Director, where he was responsible for unit strategy, quality systems, regulatory compliance, workforce development, and financial sustainability.

Alongside his operational leadership, Professor Hammond has a strong research interest in trial methodology, innovation, and efficiency. He has led and contributed to several NIHR-funded studies focused on improving trial conduct, including research on electronic consent implementation, automated health record linkage, and screening and recruitment processes. He is currently leading work exploring the operational and financial challenges associated with trial close-out and long-term data archiving, an increasingly important issue for the sustainability of clinical research.

His current methodological interests focus on decentralised and hybrid clinical trial approaches and on improving equality, diversity, and inclusion in research participation. He is a co-applicant on the PRACTICALs (Promoting Accessibility in Clinical Trials) programme, which aims to reduce barriers to trial participation through the development of inclusive, accessible trial processes and training resources.

Professor Hammond plays an active role in the UK clinical trials community. He is a member of the UKCRC Clinical Trials Unit Directors Group and serves as a panel member for the NIHR Research for Patient Benefit (RfPB) programme, contributing to national funding and research strategy. He has extensive experience in research governance and regulatory compliance.

By combining methodological research with senior operational oversight, Professor Hammond’s work aims to support the delivery of efficient, inclusive, and high-integrity clinical trials that better reflect real-world patient populations.

Research interests

Clinical trial methodology, design, and delivery, with a focus on high-quality multicentre randomised controlled trials.

Innovation in clinical trial conduct, including decentralised and hybrid trial models and the use of digital tools to improve efficiency.

Development and evaluation of electronic consent (eConsent).

Screening, recruitment, and retention strategies, including methodological approaches to improving recruitment efficiency and transparency.

Equality, diversity, and inclusion (EDI) in clinical research, with a focus on reducing barriers to participation and improving accessibility of trials.

Governance, regulation, and quality systems in clinical trials.

Sustainability of clinical trials infrastructure, including trial close-out processes, post-funding legacy activities, and long-term data archiving.

Integration of methodological research with Clinical Trials Unit leadership to strengthen applied health research practice and impact.

Publications

Journal articles

  • Meiser‐Stedman R, Allen L, Ashford P, Beeson E, Byford S, Danese A, Farr A, Finn J, Goodall B, Grainger L , Hammond M et al (2025) . World Psychiatry, 24(3), 422-434.
  • Smith TO, Khoury R, Welsh A, Hanson S, Grant K, Clark A, Ashford P-A, Hammond M, Pond M, Crowther C , Dures E et al (2025) . Rheumatology, 64(Supplement_3).
  • Smith T, Khoury R, Welsh A, Crowther C, Hanson S, Grant K, Clark AB, Ashford P-A, Hammond M, Pond M , Dures E et al (2025) . BMJ Open, 15(4), e095069-e095069.
  • Elzubeir A, High J, Hammond M, Shepstone L, Pond M, Walmsley M, Trivedi P, Culver E, Aithal G, Dyson J , Thorburn D et al (2025) . BMJ Open Gastroenterology, 12(1), e001596-e001596.
  • Jones M, Cahn A, Chaudhuri N, Clark AB, Forrest I, Hammond M, Jones S, Maher TM, Parfrey H, Raghu G , Simpson AJ et al (2025) . BMJ Open, 15(2), e088604-e088604.
  • Lee TTM, Collett C, Bergford S, Hartnell S, Scott EM, Lindsay RS, Hunt KF, McCance DR, Reynolds RM, Wilinska ME , Sibayan J et al (2025) . The Lancet Diabetes & Endocrinology, 13(3), 210-220.
  • Kishita N, Gould RL, McCracken LM, Khondoker M, Turner DA, Ashford P-A, Flanagan E, Czyznikowska B, Richmond E, Riggey M , Trucco AP et al (2024) . Contemporary Clinical Trials, 146, 107685-107685.
  • Whalen W, Berger K, Kim JS, Simmons W, Ma S-F, Kaner RJ, Martinez FJ, Anstrom KJ, Parfrey H, Maher TM , Hammond M et al (2024) . American Journal of Respiratory and Critical Care Medicine, 210(4), 508-511.
  • Lee TTM, Collett C, Bergford S, Hartnell S, Murphy HR, Scott EM, Lindsay RS, Hunt KF, McCance DR, Barnard-Kelly K , Rankin D et al (2024) . Obstetric Anesthesia Digest, 44(2), 102-103.
  • Mioshi E, Grant K, Flanagan E, Heal S, Copsey H, Gould RL, Hammond M, Shepstone L & Ashford PA (2024) . Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 25(5-6), 506-516.
  • Lee TTM, Collett C, Bergford S, Hartnell S, Scott EM, Lindsay RS, Hunt KF, McCance DR, Barnard-Kelly K, Rankin D , Lawton J et al (2024) . Obstetrical & Gynecological Survey, 79(4), 191-193.
  • Lee TTM, Collett C, Bergford S, Hartnell S, Scott EM, Lindsay RS, Hunt KF, McCance DR, Barnard-Kelly K, Rankin D , Lawton J et al (2024) Automated closed-loop insulin delivery for the management of type 1 diabetes during pregnancy: the AiDAPT RCT.
  • Lee TTM, Collett C, Bergford S, Hartnell S, Scott EM, Lindsay RS, Hunt KF, McCance DR, Barnard-Kelly K, Rankin D , Lawton J et al (2023) . New England Journal of Medicine, 389(17), 1566-1578.
  • MURPHY HR, LEE TTM, COLLETT C, HARTNELL S, SCOTT EM, LINDSAY RS, HUNT KF, MCCANCE DR, HAMMOND M, SHEPSTONE LEE , WILINSKA ME et al (2023) . Diabetes, 72(Supplement_1).
  • Hammond MP, Kolasa J & Fung P (2023) . Oikos, 2023(7).
  • Broad A, Rees M, Knott N, Swadling D, Hammond M, Ingleton T, Morris B & Davis AR (2023) . Science of The Total Environment, 863, 160717-160717.
  • Hammond M, Vaccaro DA & Parkin G (2022) . Polyhedron, 222, 115642-115642.
  • Lee TTM, Collett C, Man M-S, Hammond M, Shepstone L, Hartnell S, Gurnell E, Byrne C, Scott EM, Lindsay RS , Morris D et al (2022) . BMC Pregnancy and Childbirth, 22(1).
  • Carswell AT, Eastman KG, Casey A, Hammond M, Shepstone L, Payerne E, Toms AP, MacKay JW, Swart AM, Greeves JP & Fraser WD (2021) . Trials, 22(1).
  • Allen L, Ashford P-A, Beeson E, Byford S, Chow J, Dalgleish T, Danese A, Finn J, Goodall B, Grainger L , Hammond M et al (2021) . BMJ Open, 11(7), e047600-e047600.
  • Wilson AM, Clark AB, Cahn A, Chilvers ER, Fraser W, Hammond M, Livermore DM, Maher TM, Parfrey H, Swart AM , Stirling S et al (2021) Co-trimoxazole to reduce mortality, transplant, or unplanned hospitalisation in people with moderate to very severe idiopathic pulmonary fibrosis: the EME-TIPAC RCT.
  • Wilson AM, Clark AB, Cahn T, Chilvers ER, Fraser W, Hammond M, Livermore DM, Maher TM, Parfrey H, Swart AM , Stirling S et al (2020) . JAMA, 324(22), 2282-2282.
  • Hammond M, Loreau M, de Mazancourt C & Kolasa J (2020) . Ecosphere, 11(4).
  • Alexandre L, Clark AB, Walton S, Lewis MP, Kumar B, Cheong EC, Warren H, Kadirkamanathan SS, Parsons SL, Dresner SM , Sims E et al (2020) . BJS Open, 4(1), 59-70.
  • Leavey N, Hammond SP, Shepstone L, Cross J, Zetterberg H, Cunningham C, MacLullich A, Leiv Otto Watne , Minihane AM, Ballard C , Knapskog A-B et al (2019) . BMC Neurology, 19(1).
  • Hammond M, Clark AB, Cahn AP, Chilvers ER, Fraser WD, Livermore DM, Maher TM, Parfrey H, Swart AM, Stirling S , Thickett D et al (2018) . Trials, 19(1).
  • Al-Harbi A, Kriegel B, Gulati S, Hammond MJ & Parkin G (2017) . Inorganic Chemistry, 56(24), 15271-15284.
  • Doyle GA, Crist RC, Karatas ET, Hammond MJ, Ewing AD, Ferraro TN, Hahn C-G & Berrettini WH (2017) . Neuropsychopharmacology, 42(13), 2602-2611.
  • Doyle GA, Doucet‐O'Hare TT, Hammond MJ, Crist RC, Ewing AD, Ferraro TN, Mash DC, Kazazian HH & Berrettini WH (2017) . Brain and Behavior, 7(5).
  • Hammond MJ & Fawaz SA (2016) . Engineering Fracture Mechanics, 153, 25-34.
  • Hammond MP & Kolasa J (2016) . Oikos, 125(6), 849-860.
  • Greer JM, Galyon Dorman SE & Hammond MJ (2011) . Engineering Fracture Mechanics, 78(9), 2088-2094.
  • Linnett RJ, Billany RE, Fletcher A, Hammond M, Robertson N, Warden C & Ashford P-A () . Trials, 27(1).
  • Hammond M, Ashford P, High J, Clark LV, Howard G, Jones M, Stirling S & West C () . Trials, 25(1).
  • Leach FCP, Peckham MS & Hammond MJ () . Atmosphere, 11(4), 355-355.
  • Hammond MP & Kolasa J () . PLoS ONE, 9(2), e89245-e89245.

Conference proceedings

  • Wilson A, Hammond M, Clark A, Cahn A, Chilvers ER, Fraser W, Livermore D, Maher TM, Parfrey H, Swart AM , Stirling S et al (2020) . B16. ILD THERAPY II (pp A2753-A2753)
  • Hammond MJ & Fawaz SA () . Advanced Materials Research, Vol. 891-892 (pp 784-790)

Preprints

  • Hammond M, Ashford P, High J, Clark L, Howard G, Jones M, Stirling S & West C (2024) , Springer Science and Business Media LLC.
  • Allen L, Ashford P-A, Beeson E, Byford S, Chow J, Dalgleish T, Danese A, Finn J, Goodall B, Grainger L , Hammond M et al (2021) , Center for Open Science.
Professional activities and memberships

Member, UKCRC Clinical Trials Unit Directors Group

Panel Member, NIHR Research for Patient Benefit (RfPB) Programme

Member, Health Research Authority (HRA) Bromley NHS Research Ethics Committee (REC)