Dr Margaret Paggiosi

BSc (Hons), PhD

School of Medicine and Population Health

Research Fellow

Research Fellow

m.a.paggiosi@sheffield.ac.uk
+44 114 215 9697
Metabolic Bone Centre (Sorby Wing), Northern General Hospital

Full contact details

Dr Margaret Paggiosi
School of Medicine and Population Health
Metabolic Bone Centre (Sorby Wing)
Northern General Hospital
Herries Road
Sheffield
S5 7AU
Profile

For enquiries, please contact - iicd-om-operational@sheffield.ac.uk

I am the Research Lead for Bone Densitometry for the Mellanby Centre for Bone Research, Academic Unit of Bone Metabolism, Department of Oncology and Metabolism, ±¬ÁÏTV, UK.

I completed my undergraduate studies at Sheffield Hallam University, UK and attained a BSc Honours degree in Biomedical Technology. In 1998, I received my PhD in Exercise Physiology from Sheffield Hallam University.

In 1996, I joined the Department of Human Metabolism and Clinical Biochemistry, ±¬ÁÏTV to work as a DXA Scanning Technician and Research Associate. I now hold the position of Research Fellow.

I am responsible for the provision of the Academic Unit of Bone Metabolism’s bone densitometry service to internal and external organisations and investigators.

I have considerable expertise in a wide variety of bone densitometry and image analysis techniques. I am the Radiation Protection Supervisor (RPS) for the bone imaging work conducted at the NIHR Clinical Research Facility at the Northern General Hospital, Sheffield.

I have published over 20 articles in peer-reviewed journals and present my work at national and international conferences.

Research interests

My current research interests include the evaluation and application of high-resolution peripheral quantitative computed tomography, the study of bone microstructural properties and strength and the evaluation of treatment effects using bone densitometry techniques.

I have considerable expertise in the field of vertebral fracture identification. Of particular interest currently is the development of a computer-assisted diagnostic tool to automate the reading of spine images, using the algorithm-based qualitative (ABQ) method, to provide an accurate and reliable means of identifying vertebral fractures.

Publications

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All publications

Journal articles

  • Schini M, Paggiosi MA, Gossiel F, Cummings SR & Eastell R (2026) . J Bone Miner Res.
  • Aldieri A, Bhattacharya P, Paggiosi M, Eastell R & Grassi L (2026) . Bone, 117830-117830.
  • Vazquez DC, Zarecki P, Duseja A, Hackl M, Glüer KC, Reid DM, Roux C, Armbrecht G, Gossiel F, Paggiosi M , Evans D et al (2025) . Journal of the Endocrine Society, 9(Supplement_1).
  • Gibson FG, Paggiosi MA, Handforth C, Brown JE, Li X, Dall'Ara E & Verbruggen SW (2025) . Bone, 195.
  • Handforth C, Paggiosi MA, Jacques R, Gossiel F, Eastell R, Walsh JS & Brown JE (2024) . Journal of Bone Oncology, 47.
  • Brown J, Paggiosi M, Rathbone E, Dodwell D, Cameron D, Gregory W, Eastell R & Coleman R (2024) . Journal of Bone Oncology, 45, 100529-100529.
  • Aldieri A, Paggiosi M, Eastell R, Bignardi C, Audenino AL, Bhattacharya P & Terzini M (2024) . Bone, 182, 117051-117051.
  • Walle M, Duseja A, Whittier DE, Vilaca T, Paggiosi M, Eastell R, Müller R & Collins CJ (2024) . Journal of Bone and Mineral Research, 39(2), 85-94.
  • Brown J, Paggiosi MA, Rathbone E, Gregory W, Bertelli G, Din O, McCloskey E, Dodwell D, Cameron D, Eastell R & Coleman R (2024) . Journal of Bone and Mineral Research, 39(1), 8-16.
  • Vilaca T, Evans A, Gossiel F, Paggiosi M, Eastell R & Walsh JS (2022) . European Journal of Endocrinology, 187(6), 743-750.
  • Aldieri A, Terzini M, Audenino AL, Bignardi C, Paggiosi M, Eastell R, Viceconti M & Bhattacharya P (2022) . Annals of Biomedical Engineering, 50(3), 303-313.
  • Aldieri A, Bhattacharya P, Paggiosi M, Eastell R, Audenino AL, Bignardi C, Morbiducci U & Terzini M (2022) . Annals of Biomedical Engineering, 50(2), 211-221.
  • Vilaca T, Paggiosi M, Walsh JS, Selvarajah D & Eastell R (2021) . Journal of Bone and Mineral Research, 36(6), 1048-1059.
  • Du J, Hartley C, Brooke-Wavell K, Paggiosi MA, Walsh JS, Li S & Silberschmidt VV (2021) . Osteoporosis International, 32(5), 907-919.
  • Paggiosi M, Naganathan DGN, Undre U, Peel N & Eastell R (2021) . Bone Reports, 14, 101050-101050.
  • Salam S, Gallagher O, Gossiel F, Paggiosi M, Eastell R & Khwaja A (2021) . Bone, 143.
  • Altai Z, Montefiori E, van Veen B, A. Paggiosi M, McCloskey EV, Viceconti M, Mazzà C & Li X (2021) . PLoS ONE, 16(2).
  • Montefiori E, Kalkman B, Henson W, Paggiosi M, McCloskey E & Mazza C (2020) . PLoS ONE, 15(12).
  • Fennimore DJ, Digby M, Paggiosi M, Arundel P, Bishop NJ, Dimitri P & Offiah AC (2020) . Pediatric Radiology, 50, 1781-1787.
  • Devaraja J, Jacques R, Paggiosi M, Clark C & Dimitri P (2020) . JBMR Plus, 4(11).
  • Vilaca T, Paggiosi M, Walsh J, Selvarajah D & Eastell R (2020) . Bone Reports, 13.
  • Paggiosi MA, Peel N, McCloskey E, Walsh JS & Eastell R (2020) . Bone Reports, 13.
  • Paggiosi MA, Debono M, Walsh JS, Peel NFA & Eastell R (2020) . Osteoporosis International, 31(4), 667-675.
  • Gossiel F, Paggiosi MA, Naylor KE, McCloskey EV, Walsh J, Peel N & Eastell R (2020) . Bone, 131.
  • Du J, Brooke-Wavell K, Paggiosi MA, Hartley C, Walsh JS, Silberschmidt VV & Li S (2019) . Bone, 121, 139-148.
  • Naylor KE, McCloskey EV, Jacques RM, Peel NFA, Paggiosi MA, Gossiel F, Walsh JS & Eastell R (2019) . Osteoporosis International, 30(4), 917-922.
  • (2018) Bone Research Society Abstracts. JBMR plus, 2(Suppl ), 1-50.
  • Paggiosi MA, Yang L, Blackwell D, Walsh JS, McCloskey E, Peel N & Eastell R (2018) . Osteoporosis International, 29(6), 1367-1378.
  • Naylor KE, Bradburn M, Paggiosi MA, Gossiel F, Peel NFA, McCloskey EV, Walsh JS & Eastell R (2018) . Osteoporosis International, 29(6), 1407-1417.
  • Salam S, Gallagher O, Gossiel F, Paggiosi M, Khwaja A & Eastell R (2018) . Journal of the American Society of Nephrology, 29(5), 1557-1565.
  • Gossiel F, Scott JR, Paggiosi MA, Naylor KE, McCloskey EV, Peel NFA, Walsh JS & Eastell R (2018) . Journal of Clinical Endocrinology and Metabolism, 103(4), 1302-1309.
  • Metcalf LM, Dall'Ara E, Paggiosi MA, Rochester JR, Vilayphiou N, Kemp GJ & McCloskey EV (2018) . Bone, 106, 69-77.
  • Walsh JS, Gossiel F, Scott JR, Paggiosi MA & Eastell R (2017) . Bone, 99, 8-13.
  • Digby MG, Bishop NJ, Paggiosi MA & Offiah AC (2016) . Archives of Disease in Childhood.education and Practice Edition , 101(5), 268-270.
  • Gregson CL, Wheeler L, Hardcastle SA, Appleton LH, Addison KA, Brugmans M, Clark GR, Ward KA, Paggiosi M, Stone M , Thomas J et al (2016) . Journal of Bone and Mineral Research, 31(3), 640-649.
  • Naylor KE, Jacques RM, Paggiosi M, Gossiel F, Peel NF, McCloskey EV, Walsh JS & Eastell R (2015) . Osteoporosis International.
  • Evans AL, Paggiosi MA, Eastell R & Walsh JS (2015) . Journal of Bone and Mineral Research, 30(5), 920-928.
  • Paggiosi MA, Peel NFA & Eastell R (2015) . Osteoporosis International, 26(6), 1773-1780.
  • Dimitri P, Jacques RM, Paggiosi M, King D, Walsh J, Taylor ZA, Frangi AF, Bishop N & Eastell R (2014) . Journal of Clinical Endocrinology & Metabolism, 100(2), 594-602.
  • Paggiosi MA, Peel N, McCloskey E, Walsh JS & Eastell R (2014) . Osteoporosis International, 25(12), 2729-2741.
  • Paggiosi MA, Eastell R & Walsh JS (2014) . Calcified Tissue International, 94(2), 191-201.
  • Finigan J, Naylor K, Paggiosi MA, Peel NF & Eastell R (2013) . Osteoporosis International, 24(11), 2879-2886.
  • Gregson CL, Paggiosi MA, Crabtree N, Steel SA, McCloskey E, Duncan EL, Fan B, Shepherd JA, Fraser WD, Smith GD & Tobias JH (2013) . The Journal of Clinical Endocrinology & Metabolism, 98(2), 818-828.
  • Walsh JS, Paggiosi MA & Eastell R (2012) . The Journal of Clinical Endocrinology & Metabolism, 97(9), 3342-3348.
  • Paggiosi MA, Finigan J, Peel N, Eastell R & Ferrar L (2012) . Journal of Clinical Densitometry, 15(4), 454-460.
  • Paggiosi MA, Barkmann R, Glüer CC, Roux C, Reid DM, Felsenberg D, Bradburn M & Eastell R (2012) . Osteoporosis International, 23(12), 2815-2828.
  • Paggiosi MA, Glueer CC, Roux C, Reid DM, Felsenberg D, Barkmann R & Eastell R (2011) . Osteoporosis International, 22(2), 721-729.
  • Paggiosi MA, Clowes JA, Finigan J, Naylor KE & Peel NF (2010) Performance of quantitative ultrasound measurements of bone for monitoring raloxifine therapy. Journal of Clinical Densitometry, 13(4), 441-450.
  • Naylor KE, Clowes JA, Finigan J, Paggiosi MA, Peel NFA & Eastell R (2010) . Bone, 46(3), 592-597.
  • Paggiosi MA, Blumsohn A, Barkmann R & Eastell R (2005) . Journal of Clinical Densitometry, 8(4), 436-444.
  • Schini M, Gossiel F, Paggiosi MA, Hilditch SL, More S, Modlin I & Eastell R () . Journal of Bone and Mineral Research.
  • Naylor KE, Jacques RM, Paggiosi M, Gossiel F, Peel NF, McCloskey EV, Walsh JS & Eastell R () . Osteoporosis International.
  • Dimitri P, Paggiosi M, King D, Bishop N & Eastell R () . Endocrine Abstracts.
  • Naylor K, Paggiosi M, Gossiel F, McCloskey E, Peel N, Walsh J & Eastell R () . Bone Abstracts.
  • Gossiel F, Naylor K, McCloskey E, Peel N, Walsh J, Paggiosi M & Eastell R () . Bone Abstracts.
  • Paggiosi M, Peel N & Eastell R () . Bone Abstracts.

Conference proceedings

  • Vilaca T, Gossiel F, Paggiosi MA & Eastell R (2025) Calcium Isotope Measurement (CIM): Use as a Biomarker of Mineral Balance During Bisphosphonate Treatment and Withdrawal. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 40
  • Walle M, Duseja A, Whittier D, Vilaca T, Paggiosi M, Eastell R, Mueller R & Collins C (2023) Bone remodelling and responsiveness to mechanical stimuli in type 1 diabetes mellitus: the role of neuropathy. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 38 (pp 390-390)
  • Duseja A, Gossiel F, Paggiosi M, Walsh J, Frost M, Hermann P & Eastell R (2023) Bone turnover and bone balance in type 2 diabetes. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 38 (pp 312-312)
  • Alshamrani HA, Paggiosi MA, Rigby AS, Bishop NJ & Offiah AC (2020) EFFECT OF HIGH DOSE VITAMIN D AND WHOLE BODY VIBRATION ON BONE DENSITY OF THE DISTAL TIBIA AS MEASURED BY HR-PQCT, SERUM 25(OH)D AND PTH. OSTEOPOROSIS INTERNATIONAL, Vol. 31(SUPPL 1) (pp S443-S444)
  • Vilaca T, Paggiosi M, Gossiel F, Selvarajah D, Walsh J & Eastell R (2020) Bone Health in Type 1 Diabetes with and without Neuropathy; a Cross-Section Study. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 35 (pp 51-51)
  • Salam S, Paggiosi M, Gallagher O, Eastell R & Khwaja A (2019) . Nephrology Dialysis Transplantation, Vol. 34(Supplement_1). Budapest, Hungary, 13 June 2019 - 13 June 2019.
  • Salam S, Paggiosi M, Gallagher O, Eastell R & Khwaja A (2019) VASCULAR CALCIFICATION IN ADVANCED CKD AND ITS RELATIONSHIP WITH BONE MICROSTRUCTURES. NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol. 34
  • Paggiosi M, Barkmann R, Glueer C, Roux C, Reid DM, Felsenberg D & Eastell R (2010) A EUROPEAN MULTI-CENTRE COMPARISON OF QUANTITATIVE ULTRASOUND MEASUREMENT VARIABLES. OSTEOPOROSIS INTERNATIONAL, Vol. 21 (pp S487-S488)
  • Paggiosi MA, Glueer CC, Roux C, Reid DM, Felsenberg D, Barkmann R & Eastell R (2009) . Bone, Vol. 44 (pp S234-S235)
  • Graves H, Paggiosi M, Charlesworth D & Eastell R (2009) SITE-SPECIFIC MEASUREMENTS OF BONE: A COMPARISION OF DIFFERENT MODALITIES. OSTEOPOROSIS INTERNATIONAL, Vol. 20 (pp S308-S309)
  • Devaraja J, Dimitri P, Paggiosi M, Clark C, Jacques R & Bishop N () . Bone Abstracts

Datasets

  • Tai ZA, Montefiori E, Veen BV, Paggiosi M, McCloskey E, Viceconti M, Mazza C & Li X .
  • Montefiori E, Kalkman B, Mazza C, Paggiosi M, McCloskey E & Henson W .

Preprints

  • Gibson FG, Ding Z, Paggiosi MA, Handforth C, Brown JE, Li X, Dall’Ara E & Verbruggen SW (2026) , openRxiv.
Grants
  • Arthritis Research UK Medical Technologies Proof of Concept Award. Development and Evaluation of a Functional Prototype for the Automated Identification of Osteoporotic Vertebral Fractures: VERDICT. Frangi AF (PI), Paggiosi MA (co-applicant), Eastell R, Pozo Soler J, Peel NFA, Jacques R. Project grant: April 2017 to March 2019.
  • Weston Park Hospital Cancer Charity Louise Victoria Craddock Memorial fund. Equipment Purchase: DXA Machine That Is Particularly Effective At Measuring Body Fat. Paggiosi MA (PI), Eastell R, Brown JE. Capital project grant: November 2016 to April 2017.
  • ±¬ÁÏTV Innovation, Impact and Knowledge Exchange (IIKE) Award. Cal-CT: Optimising calcaneus microstructure measurements for the assessment of skeletal strength in osteoporosis. EV McCloskey (PI), Frangi AF, Metcalf LM, Paggiosi MA (co-applicant). Project grant: October 2015 to March 2017.
  • ±¬ÁÏTV through the MRC Confidence in Concept Scheme. VERTEBRAL FRACTURE: Vertebral analysis and fracture risk assessment from 2D DXA scans. Eastell R (PI), Frangi AF, Paggiosi MA (co-applicant), Pozo Soler J. Project grant: July 2014 to June 2015
Teaching activities

I lecture on the Mellanby Centre for Bone Research ‘Identification of Vertebral Fractures’ training courses and on the Academic Unit of Bone Metabolism’s teaching course.

I perform ad hoc teaching including the practical aspects of bone imaging techniques, radiation protection to students and members of staff.

Professional activities and memberships

I am a member of the American Society for Bone and Mineral Research, the Society of Radiographers and a professional member of the National Osteoporosis Society.

I act as co-organiser and co-chair of the Allied Health Professional session for the European Calcified Tissue Society at their annual conferences.

I am a regular reviewer of articles for key journals including Osteoporosis International, the Journal of Clinical Densitometry and Bone.