Dr Irina-Alexandra Bacila

PhD, PGDip, MRCPCH

School of Medicine and Population Health

NIHR Academic Clinical Lecturer in Paediatrics

Dr Irina Bacila
Dr Irina Bacila
Profile picture of Dr Irina Bacila
i.bacila@sheffield.ac.uk
+44 114 215 9022
EU10, E Floor, The Medical School

Full contact details

Dr Irina-Alexandra Bacila
School of Medicine and Population Health
EU10, E Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk

I joined the ±¬ÁÏTV in 2018 when I started a four-year post as Clinical Research Fellow in Paediatrics. This marked the beginning of my research activity within the Department of Oncology and Metabolism at ±¬ÁÏTV and the Endocrine Team at Sheffield Children’s Hospital. During this time, I also completed a PhD in Endocrinology studying metabolic complications in congenital adrenal hyperplasia (CAH). I am dedicated to developing a career as a Clinical Academic, and I am currently working as a Clinical Lecturer in Paediatrics, dividing my time between academic work in the School of Medicine and Population Health, and clinical training in Paediatric Endocrinology at The Sheffield Children’s Hospital.

Qualifications
  • PhD in Endocrinology, ±¬ÁÏTV, Sheffield (2023)
  • Postgraduate Diploma in Child Health, Leeds University, Leeds (2018)
  • Membership of the Royal College of Paediatrics and Child Health (MRCPCH) (2015)
  • Specialty Exam in Paediatrics, Cluj, Romania, Qualification: Specialty Doctor in Paediatrics (2012)
  • University of Medicine and Pharmacy, Cluj, Romania (2007)
Research interests

My research interests are adrenal disease, disorders of steroid synthesis and disorders of sexual development. I have explored these areas in clinical research involving patients with congenital adrenal hyperplasia (CAH) and also in Basic Science research, using zebrafish models of abnormal steroid synthesis. I am also interested in using bioinformatics in combination with metabolomics and transcriptomics to explore molecular mechanisms involved in the pathophysiology of endocrine and metabolic disease.

Publications

Show: Featured publications All publications

Journal articles

  • Balagamage C, Lawrence NR, Krone R, Bacila IA & Krone NP (2024) . Hormone Research in Paediatrics, 97(4), 315-325.
  • Bacila I, Lawrence NR, Badrinath SG, Balagamage C & Krone NP (2024) . Clinical Endocrinology, 101(4), 300-310.
  • Eachus H, Oberski L, Paveley J, Bacila I, Ashton J-P, Esposito U, Seifuddin F, Pirooznia M, Elhaik E, Placzek M , Krone N et al (2023) . Disease Models & Mechanisms, 16(9).
  • Lawrence NR, Bacila I, Dawson J, Mahdi S, Alvi S, Cheetham TD, Crowne E, Das U, Dattani MT, Davies JH , Gevers E et al (2023) . The Journal of Clinical Endocrinology & Metabolism, 109(1), e336-e346.
  • Bacila I, Lawrence NR, Mahdi S, Alvi S, Cheetham TD, Crowne E, Das U, Dattani MT, Davies JH, Gevers E , Krone RE et al (2022) . European Journal of Endocrinology, 187(4), 543-553.
  • Lawrence N, Bacila I, Dawson J, Bryce J, Ali SR, van den Akker ELT, Bachega TASS, Baronio F, Birkebæk NH, Bonfig W , Claahsen van der Grinten H et al (2022) . Clinical Endocrinology, 97(5), 551-561.
  • Bacila I, Cunliffe VT & Krone NP (2021) . Molecular and Cellular Endocrinology, 535, 111372-111372.
  • Bacila I, Freeman N, Daniel E, Sandrk M, Bryce J, Ali SR, Yavas Abalı Z, Atapattu N, Bachega TA, Balsamo A , Birkebæk N et al (2021) . European Journal of Endocrinology, 184(4), 553-563.
  • Bacila I, Adaway J, Hawley J, Mahdi S, Krone R, Patel L, Alvi S, Randell T, Gevers E, Dattani M , Cheetham T et al (2019) . The Journal of Clinical Endocrinology & Metabolism, 104(12), 6417-6429.
  • Bacila I-A, Elder C & Krone N (2019) . Archives of Disease in Childhood, 104(12), 1223-1228.

All publications

Journal articles

  • Lawrence NR, Bacila I, Tonge J, Tucker A, Dawson J, Lang Z-Q, Krone NP, Dhiman P & Collins GS (2025) . Diagnostic and Prognostic Research, 9(1).
  • Bacila I, Oberski L, Li N, Storbeck K-H, Cunliffe VT & Krone N (2025) . Biology Open, 14(9).
  • Bacila IA, Lawrence NR, Alvi S, Cheetham TD, Crowne E, Das U, Dattani MT, Davies JH, Gevers E, Keevil B , Krone RE et al (2025) . European Journal of Endocrinology, 193(3), 329-339.
  • Lawrence NR, Bacila I, Tonge J, Dawson J, Collins GS, Lang Z-Q, Bryce J, Alimussina M, Chen M, Ali SR , Adam S et al (2025) . European Journal of Endocrinology, 192(5), 529-539.
  • Balagamage C, Lawrence NR, Krone R, Bacila IA & Krone NP (2024) . Hormone Research in Paediatrics, 97(4), 315-325.
  • Bacila I, Lawrence NR, Badrinath SG, Balagamage C & Krone NP (2024) . Clinical Endocrinology, 101(4), 300-310.
  • Eachus H, Oberski L, Paveley J, Bacila I, Ashton J-P, Esposito U, Seifuddin F, Pirooznia M, Elhaik E, Placzek M , Krone N et al (2023) . Disease Models & Mechanisms, 16(9).
  • Lawrence NR, Bacila I, Dawson J, Mahdi S, Alvi S, Cheetham TD, Crowne E, Das U, Dattani MT, Davies JH , Gevers E et al (2023) . The Journal of Clinical Endocrinology & Metabolism, 109(1), e336-e346.
  • Bacila I, Lawrence NR, Mahdi S, Alvi S, Cheetham TD, Crowne E, Das U, Dattani MT, Davies JH, Gevers E , Krone RE et al (2022) . European Journal of Endocrinology, 187(4), 543-553.
  • Lawrence N, Bacila I, Dawson J, Bryce J, Ali SR, van den Akker ELT, Bachega TASS, Baronio F, Birkebæk NH, Bonfig W , Claahsen van der Grinten H et al (2022) . Clinical Endocrinology, 97(5), 551-561.
  • Bacila I, Cunliffe VT & Krone NP (2021) . Molecular and Cellular Endocrinology, 535, 111372-111372.
  • Bacila I-A, Lawrence N, Mahdi S, Alvi S, Cheetham T, Crowne E, Das U, Dattani M, Davies JH, Gevers EF , Krone R et al (2021) . Journal of the Endocrine Society, 5(Supplement_1), A717-A717.
  • Bacila I, Freeman N, Daniel E, Sandrk M, Bryce J, Ali SR, Yavas Abalı Z, Atapattu N, Bachega TA, Balsamo A , Birkebæk N et al (2021) . European Journal of Endocrinology, 184(4), 553-563.
  • Bacila I, Adaway J, Hawley J, Mahdi S, Krone R, Patel L, Alvi S, Randell T, Gevers E, Dattani M , Cheetham T et al (2019) . The Journal of Clinical Endocrinology & Metabolism, 104(12), 6417-6429.
  • Bacila I-A, Elder C & Krone N (2019) . Archives of Disease in Childhood, 104(12), 1223-1228.
  • Ferguson GR, Bacila IA & Swamy M (2016) . BMJ Open, 6(4), e010054-e010054.
  • Lawrence NR, Bacila I, Tonge J, Balagamage C, Dawson J, Collins GS, Lang Z-Q, Bryce J, Alimussina M, Chen M , Ali SR et al () . European Journal of Endocrinology.
  • Tonge JJ, Bacila I & Krone NP () . Drugs.
  • Bacila IA, Oberski L, Cunliffe V & Krone N () . Endocrine Abstracts.
  • Lawrence NR, Bacila IA, Collins GS, Dawson J, Lang Z-Q, Ji X, Ahmed SF, Alvi S, Bath LE, Blair J , Cheetham T et al () . Hormone Research in Paediatrics, 98(3), 296-306.

Conference proceedings

  • Lawrence NR, Bacila I, Tonge J, Dawson J, Collins GS, Lang Z-Q, Bryce J, Alimussina M, Chen M, Ali SR , Adam S et al (2024) Variation in Blood Pressure in Young Adults with 21a-Hydroxylase Deficiency: Longitudinal Multilevel Modelling of Data from the I-CAH Registry. HORMONE RESEARCH IN PAEDIATRICS, Vol. 97 (pp 154-155)
  • Panchigar K, Tonge J, Bacila I, Bryce J, Alimussina M, Koley S, Ahmed SF, Lawrence NR & Krone N (2024) An exploration of a data visualisation web application for rare disease registries. HORMONE RESEARCH IN PAEDIATRICS, Vol. 97 (pp 514-514)
  • Tonge JJ, Bacila I, Lawrence NR, Alvi S, Cheetham TD, Crowne E, Das U, Dattani MT, Davies JH, Gevers E , Keevil B et al (2024) Non-invasive biochemical monitoring for Congenital Adrenal Hyperplasia: use of urinary steroid metabolites and salivary 17α-Hydroxyprogesterone. HORMONE RESEARCH IN PAEDIATRICS, Vol. 97 (pp 209-210)
  • Lawrence NR, Bacila I, Tonge J, Dawson J, Collins GS, Lang Z-Q, Bryce J, Alimussina M, Chen M, Ali SR , Adam S et al (2024) Impact of Fludrocortisone on Blood Pressure in Young Children Under 5 with CAH in the I-CAH Registry: Autoregressive Causal Inference Analysis. HORMONE RESEARCH IN PAEDIATRICS, Vol. 97 (pp 153-154)
  • Bacila IA, Lawrence NR, Balagamage C, Bryce J, Ali SR, Alimussina M, Chen M, Arya VB, Atapattu N, Bachega TA , Barat P et al (2024) Real world data analysis of contemporary therapy and its association to anthropometric outcomes in 1500 patients with congenital adrenal hyperplasia (CAH). HORMONE RESEARCH IN PAEDIATRICS, Vol. 97 (pp 43-44)
  • Bacila IA, Lawrence NR, Alvi S, Cheetham TD, Crowne E, Das U, Dattani MT, Davies JH, Gevers E, Keevil B , Krone RE et al (2024) Leptin and adiponectin are associated with the glucocorticoid dose and androgen concentrations in children and young persons with congenital adrenal hyperplasia: data from the CAH-UK cohort. HORMONE RESEARCH IN PAEDIATRICS, Vol. 97 (pp 155-156)
  • Oberski L, Bacila I, Cunliffe V & Krone N (2023) The pathophysiologic response of central nervous system due to differently impaired steroidogenesis. HORMONE RESEARCH IN PAEDIATRICS, Vol. 96 (pp 27-28)
  • Bacila I, Lawrence NR, Ji X, Ahmed SF, Alvi S, Bath L, Blair J, Cheetham T, Crowne L, Davies JH , Dattani M et al (2023) National service evaluation project analysing the quality of care for children and young people with congenital adrenal hyperplasia in the United Kingdom: Data from patients and clinicians. HORMONE RESEARCH IN PAEDIATRICS, Vol. 96 (pp 418-419)
  • Bacila I, Oberski L, Cunliffe V & Krone N (2023) Metabolic effects of cortisol insufficiency are sex-depended in a zebrafish model of 21-hydroxylase deficiency. HORMONE RESEARCH IN PAEDIATRICS, Vol. 96 (pp 135-135)
  • Baker EL, Ellis J, Jayes S, Kingsley R, Lee A, Mitchell D, Peakman E, Smith DP, Watts W & Bacila IA (2023) York Paediatric Diabetes Team: A rewarding quality improvement project in children with type 1 diabetes. DIABETIC MEDICINE, Vol. 40
  • Bacila I, Li N, Eachus H, Storbeck K-H, Cunliffe VT & Krone NP (2022) Towards understanding the metabolic phenotype of glucocorticoid deficiency in 21-hydroxylase deficiency. HORMONE RESEARCH IN PAEDIATRICS, Vol. 95(SUPPL 2) (pp 79-79)
  • Lawrence NR, Bacila I, Dawson J, Ali SR, van den Akker ELT, Sartori Sanchez Bachega TA, Baronio F, Birkebaek NH, Bonfig W, van der Grinten C , Cools M et al (2022) Blood pressure (BP) status in Congenital Adrenal Hyperplasia (CAH) - longitudinal analysis of real world data from the I-CAH registry. HORMONE RESEARCH IN PAEDIATRICS, Vol. 95(SUPPL 2) (pp 112-113)
  • Lawrence NR, Bacila I-A, Mahdi S, Albi S, Cheetham TD, Crowne EC, Das U, Dawson J, Dattani MT, Davies J , Gevers E et al (2021) . Journal of the Endocrine Society, Vol. 5(Supplement_1) (pp A720-A720). Virtual meeting, 20 March 2021 - 20 March 2021.
  • Bacila I, Lawrence N, Alvi S, Cheetham T, Crowne E, Das U, Dattani M, Davies JH, Gevers E, Krone R , Kyriakou A et al (2021) Re-appraising the use of urinary steroid profiles for assessing therapy control in children with 21-hydroxylase deficiency - results from the CAH-UK cohort study. HORMONE RESEARCH IN PAEDIATRICS, Vol. 94(SUPPL 1) (pp 27-27)
  • Lawrence N, Bacila I, Dawson J, Bryce J, van den Akker EL, Sartori Sanchez Bachega TA, Baronio F, Birkebaek NH, Bonfig W, Claahsen H , Costa EC et al (2021) Variation of glucocorticoid dose and biomarkers in children with congenital adrenal hyperplasia longitudinal analysis of real world data from the I-CAH registry. HORMONE RESEARCH IN PAEDIATRICS, Vol. 94(SUPPL 1) (pp 26-26)
  • Lawrence N, Bacila I, Dawson J, Bryce J, van den Akker E, Sartori Sanchez Bachega TA, Baronio F, Birkebaek NH, Bonfig W, Claahsen H , Costa EC et al (2021) International practice of therapy monitoring in congenital adrenal hyperplasia - Real World data from the I-CAH registry. HORMONE RESEARCH IN PAEDIATRICS, Vol. 94(SUPPL 1) (pp 67-68)

Posters

  • Bacila IA, Welch R, Adam S, Faisal Ahmed S, Alimussina M, Chinnasamy E, Crowne EC, Davies JH, Davis A, Davis J , Debono M et al (2025) SAT-420 First insights into the health status of adults with CAH in the UK and Ireland - CaHASE2. ENDO 2025 Annual Meeting of the Endocrine Society.
  • Bacila IA, Lawrence N, Balagamage C, Bryce J, Ali SR, Alimussina M, Chen M, Albanese A, Amin N, Davies J , Gazdagh G et al Insights into the health provision for children with congenital adrenal hyperplasia in the UK and implementation of longitudinal collection and analysis of real-world data.
  • Devanand A, Bacila I, McDonald C & Krone N Outcomes of surgery in females with congenital adrenal hyperplasia - a scoping review of the literature.
  • AbdelBari H, Bacila I-A & Wright N Does social care involvement in children and adolescents living with obesity influence weight loss and BMI?.
  • J TJ, Bacila I, R LN, Faisal AS, Alvi S, D CT, Crowne E, Das U, T DM, H DJ , Gevers E et al Non-invasive biochemical monitoring for congenital adrenal hyperplasia (CAH) using 24-hour urinary steroid profiles.

Datasets

  • Bacila I-A .

Presentations

  • Balagamage C, Bacila I, Idkowiak J, Lawrence NR, Bryce J, Ahmed F, Alimussina M, Amr N, Arya VB, Atapattu N , Bachega T et al .
  • Bacila IA, Li N, Cunliffe V & Krone NP .
  • Balagamage C, Bacila I, R. LN, Idkowiak J, Bryce J, Alimussina M, Amr N, Bhushan AV, Atapattu N, Bachega T , Baronio F et al .