Dr Lynda Partridge

School of Biosciences

Senior Lecturer

Dr Lynda Partridge
Profile picture of Dr Lynda Partridge
l.partridge@sheffield.ac.uk
+44 114 222 4185
Firth Court

Full contact details

Dr Lynda Partridge
School of Biosciences
Firth Court
Western Bank
Sheffield
S10 2TN
Profile

I am a Senior Lecturer in the School of Biosciences and teach Immunology to students in all years of our course. After a Biological Sciences degree at the University of Birmingham (specialising in Microbiology and Genetics) I carried out my PhD in Immunology at the Medical School there. I moved to Sheffield as a postdoctoral worker and later joined the Department as a lecturer. Most of my research now focusses on the tetraspanin family of membrane proteins and their role in infection, but I also have a long-standing interest in the application of antibody techniques to research and medicine.  I鈥檓 currently Chair of the Yorkshire Branch of the Royal Society of Biology and am a Fellow of the Royal Society of Biology.

Career history

  • 1979-1982: PhD, Department of Immunology, University of Birmingham
  • 1882-1988: Post-doctoral researcher, Department of Biochemistry 爆料TV
  • 1988-1998: Lecturer, Department of Molecular Biology and Biotechnology, 爆料TV
  • 1990, 1993: Visiting Researcher, Scripps Research Clinic, La Jolla, California
  • 2009-2013: Scientific Director, Bioserv UK Ltd.
  • 1998-present: Senior Lecturer, School of Biosciences, 爆料TV

 

Qualifications
  • PhD Immunology (University of Birmingham)
  • MSc Immunology (University of Birmingham)
  • BSc Biological Sciences (University of Birmingham)
Research interests

Tetraspanins in health and disease

Tetraspanins are a highly conserved superfamily of transmembrane proteins, with the first member having appeared some 570 million years ago! They are widely expressed in multicellular organisms and are involved in basic cell functions such as motility, fusion and membrane trafficking. Tetraspanins form promiscuous associations with one another and with other membrane proteins and lipids to generate a specialised type of microdomain: the tetraspanin enriched microdomain (TEM). There are 33 tetraspanins in mammals with roles in fertility, the immune response, cancer progression and susceptibility to infections.

Our group uses specific antibodies and other tetraspanin-based reagents to investigate how these proteins function in health and disease. We have shown that tetraspanins help control the formation of multinucleated giant cells (MNGCs), which are associated with chronic inflammation and certain types of infection, particularly those caused by viruses.

We have also discovered that many pathogenic bacteria 鈥渉ijack鈥 tetraspanin microdomains as a way of attaching to host cells before causing infection. This has encouraged us to develop tetraspanin-based reagents as alternatives to antibiotics for treating infections caused by a wide range of microbes such as Staphylococcus aureus (including MRSA).

Antibodies in research

I have also had a long-standing interest in the production and use of antibodies as tools in research and medicine. In the early 1990s, I helped establish a dedicated facility at the University for Custom Production of antibodies for researchers. A related spinout company, Bioserv UK Ltd, established in 2009, specialises in the production of antibodies and other proteins from mammalian cell culture.

Publications

Show: Featured publications All publications

Journal articles

  • Urwin L, Okurowska K, Crowther G, Roy S, Garg P, Karunakaran E, MacNeil S, Partridge LJ, Green LR & Monk PN (2020) . Cells, 9(11).
  • Sangsri T, Saiprom N, Tubsuwan A, Monk P, Partridge LJ & Chantratita N (2020) . Scientific Reports, 10.
  • Elgawidi A, Mohsin MI, Ali F, Watts A, Monk PN, Thomas MS & Partridge LJ (2020) . Medical Microbiology and Immunology.
  • Elgawidi A, Mohsin MI, Ali F, Watts A, Monk PN, Thomas MS & Partridge LJ (2020) . Medical Microbiology and Immunology, 209(5), 643-652.
  • Hassuna NA, Monk PN, Ali F, Read RC & Partridge LJ (2017) . Journal of Infection, 75(2), 115-124.
  • Ventress JK, Partridge LJ, Cozens D, Read RC, MacNeil S & Monk PN (2016) . PLoS One, 11(7).
  • Rust A, Hassan HHA, Sedelnikova S, Niranjan D, Hautbergue G, Abbas SA, Partridge L, Rice D, Binz T & Davletov B (2015) . Scientific Reports, 5, 12444-12444.
  • Hulme RS, Higginbottom A, Palmer J, Partridge LJ & Monk PN (2014) . PLoS ONE, 9(12).
  • Cruz-Migoni A, Hautbergue GM, Artymiuk PJ, Baker PJ, Bokori-Brown M, Chang C-T, Dickman MJ, Essex-Lopresti A, Harding SV, Mahadi NM , Marshall LE et al (2011) . Science, 334(6057), 821-824.
  • Green LR, Monk PN, Partridge LJ, Morris P, Gorringe AR & Read RC (2011) . Infect Immun, 79(6), 2241-2249.
  • Triki膰 MZ, Monk P, Roehl H & Partridge LJ (2011) . PLoS One, 6(5), e19683.
  • Parthasarathy V, Martin F, Higginbottom A, Murray H, Moseley GW, Read RC, Mal G, Hulme R, Monk PN & Partridge LJ (2009) . Immunology, 127(2), 237-248.
  • Green LR, Issa R, Albaldi F, Urwin L, Thompson R, Khalid H, Turner CE, Ciani B, Partridge LJ & Monk PN () . mBio.
  • Rust A, Partridge L, Davletov B & Hautbergue G () . Toxins, 9(11), 344-344.

All publications

Journal articles

  • Jadi PK, Dave A, Issa R, Tabassum K, Okurowska K, Samarth A, Urwin L, Green LR, Partridge LJ, MacNeil S , Garg P et al (2023) . The Ocular Surface.
  • Greaves S, Marsay KS, Monk PN, Roehl H & Partridge LJ (2022) . PLOS ONE, 17(11).
  • Marsay KS, Greaves S, Mahabaleshwar H, Ho CM, Roehl H, Monk PN, Carney TJ & Partridge LJ (2021) . PLoS ONE, 16(11).
  • Urwin L, Okurowska K, Crowther G, Roy S, Garg P, Karunakaran E, MacNeil S, Partridge LJ, Green LR & Monk PN (2020) . Cells, 9(11).
  • Sangsri T, Saiprom N, Tubsuwan A, Monk P, Partridge LJ & Chantratita N (2020) . Scientific Reports, 10.
  • Hassuna NA, Abdel-Malek MAY, Nasif Mohamed KA, Medhat M & Partridge LJ (2020) . Access Microbiology, 2(7A).
  • Emery K, Roy S, Thokala P, Partridge L, Garg P, MacNeil S, Monk P & Karunakaran E (2020) . Journal of Visualized Experiments.
  • Elgawidi A, Mohsin MI, Ali F, Watts A, Monk PN, Thomas MS & Partridge LJ (2020) . Medical Microbiology and Immunology.
  • Elgawidi A, Mohsin MI, Ali F, Watts A, Monk PN, Thomas MS & Partridge LJ (2020) . Medical Microbiology and Immunology, 209(5), 643-652.
  • Dave A, Samarth A, Karolia R, Sharma S, Karunakaran E, Partridge L, MacNeil S, Monk P, Garg P & Roy S (2020) . Microorganisms, 8(2).
  • Champion TC, Partridge LJ, Ong S-M, Malleret B, Wong S-C & Monk PN (2018) . Frontiers in Immunology, 9.
  • Hassuna NA, Monk PN, Ali F, Read RC & Partridge LJ (2017) . Journal of Infection, 75(2), 115-124.
  • Yaseen IH, Monk PN & Partridge LJ (2017) . Biochem Soc Trans, 45(2), 465-475.
  • Ventress JK, Partridge LJ, Cozens D, Read RC, MacNeil S & Monk PN (2016) . PLoS One, 11(7).
  • Logan A, Pell VR, Shaffer KJ, Evans C, Stanley NJ, Robb EL, Prime TA, Chouchani ET, Cochem茅 HM, Fearnley IM , Vidoni S et al (2016) . Cell Metabolism, 23(2), 379-385.
  • Armanios M, de Cabo R, Mannick J, Partridge L, van Deursen J & Villeda S (2015) . Nature Medicine, 21(12), 1395-1399.
  • Rust A, Hassan HHA, Sedelnikova S, Niranjan D, Hautbergue G, Abbas SA, Partridge L, Rice D, Binz T & Davletov B (2015) . Scientific Reports, 5, 12444-12444.
  • Hulme RS, Higginbottom A, Palmer J, Partridge LJ & Monk PN (2014) . PLoS ONE, 9(12).
  • Partridge L (2014) . Trends in Endocrinology & Metabolism, 25(11), 555-557.
  • Piper MDW, Selman C, Speakman JR & Partridge L (2014) . Journal of Genetics and Genomics, 41(9), 505-512.
  • Modi N, Vohra J, Preston J, Elliott C, Van't Hoff W, Coad J, Gibson F, Partridge L, Brierley J, Larcher V & Greenough A (2014) . Archives of Disease in Childhood, 99(10), 887-891.
  • Partridge L (2014) . Philosophical Transactions of the Royal Society B: Biological Sciences, 369(1633), 20130496-20130496.
  • Niccoli T & Partridge L (2012) . Current Biology, 22(17), R741-R752.
  • Monk PN & Partridge LJ (2012) . Infect Disord Drug Targets, 12(1), 4-17.
  • Cruz-Migoni A, Hautbergue GM, Artymiuk PJ, Baker PJ, Bokori-Brown M, Chang C-T, Dickman MJ, Essex-Lopresti A, Harding SV, Mahadi NM , Marshall LE et al (2011) . Science, 334(6057), 821-824.
  • Green LR, Monk PN, Partridge LJ, Morris P, Gorringe AR & Read RC (2011) . Infect Immun, 79(6), 2241-2249.
  • Fanaei M, Monk PN & Partridge LJ (2011) . Biochem Soc Trans, 39(2), 524-528.
  • Lee SF, Chen Y, Varan AK, Wee CW, Rako L, Axford JK, Good RT, Blacket MJ, Reuter C, Partridge L & Hoffmann AA (2011) . Molecular Biology and Evolution, 28(8), 2393-2402.
  • Cochem茅 HM, Quin C, McQuaker SJ, Cabreiro F, Logan A, Prime TA, Abakumova I, Patel JV, Fearnley IM, James AM , Porteous CM et al (2011) . Cell Metabolism, 13(3), 340-350.
  • Alic N, Hoddinott MP, Vinti G & Partridge L (2011) . Aging Cell, 10(1), 137-147.
  • Partridge L, Thornton J & Bates G (2011) . Philosophical Transactions of the Royal Society B: Biological Sciences, 366(1561), 6-8.
  • Triki膰 MZ, Monk P, Roehl H & Partridge LJ (2011) . PLoS One, 6(5), e19683.
  • Partridge L (2009) . Aging Cell, 8(5), 509-513.
  • Parthasarathy V, Martin F, Higginbottom A, Murray H, Moseley GW, Read RC, Mal G, Hulme R, Monk PN & Partridge LJ (2009) . Immunology, 127(2), 237-248.
  • Hassuna N, Monk PN, Moseley GW & Partridge LJ (2009) . BioDrugs, 23(6), 341-359.
  • Milton CC & Partridge L (2008) . Journal of Insect Physiology, 54(1), 32-40.
  • Partridge L (2007) . Aging Cell, 6(5), 595-598.
  • Bass TM, Weinkove D, Houthoofd K, Gems D & Partridge L (2007) . Mechanisms of Ageing and Development, 128(10), 546-552.
  • Giannakou ME, Goss M, Jacobson J, Vinti G, Leevers SJ & Partridge L (2007) . Aging Cell, 6(4), 429-438.
  • Wright AJ, Higginbottom A, Philippe D, Upadhyay A, Bagby S, Read RC, Monk PN & Partridge LJ (2007) . Mol Immunol, 44(10), 2507-2517.
  • Scola A-M, Higginbottom A, Partridge LJ, Reid RC, Woodruff T, Taylor SM, Fairlie DP & Monk PN (2007) . J Biol Chem, 282(6), 3664-3671.
  • Ho SH, Martin F, Higginbottom A, Partridge LJ, Parthasarathy V, Moseley GW, Lopez P, Cheng-Mayer C & Monk PN (2006) . J VIROL, 80(13), 6487-6496.
  • Hamidpour M, Behrendt M, Griffiths B, Partridge L & Lindsey N (2006) . EUR J HAEMATOL, 76(4), 331-338.
  • Barnes AI, Boone JM, Jacobson J, Partridge L & Chapman T (2006) . Proceedings of the Royal Society B: Biological Sciences, 273(1589), 939-947.
  • Warner H, Anderson J, Austad S, Bergamini E, Bredesen D, Butler R, Carnes BA, Clark BFC, Cristofalo V, Faulkner J , Guarente L et al (2005) . EMBO reports, 6(11), 1006-1008.
  • Wertheim B, Kraaijeveld AR, Schuster E, Blanc E, Hopkins M, Pletcher SD, Strand MR, Partridge L & Godfray HCJ (2005) . Genome Biology, 6(11), R94-R94.
  • Martin F, Roth DM, Jans DA, Pouton CW, Partridge LJ, Monk PN & Moseley GW (2005) . J Virol, 79(17), 10839-10851.
  • Muranova TA, Ruzheinikov SN, Higginbottom A, Clipson JA, Blackburn GM, Wentworth P, Datta A, Rice DW & Partridge LJ (2004) . Acta Crystallogr D Biol Crystallogr, 60(Pt 1), 172-174.
  • Calboli FCF, Kennington WJ & Partridge L (2003) . Evolution, 57(11), 2653-2658.
  • Calboli FCF, Gilchrist GW & Partridge L (2003) . Evolution, 57(3), 566-573.
  • Higginbottom A, Takahashi Y, Bolling L, Coonrod SA, White JM, Partridge LJ & Monk PN (2003) . Biochem Biophys Res Commun, 311(1), 208-214.
  • Ruzheinikov SN, Muranova TA, Sedelnikova SE, Partridge LJ, Blackburn GM, Murray IA, Kakinuma H, Takahashi-Ando N, Shimazaki K, Sun J , Nishi Y et al (2003) . J Mol Biol, 332(2), 423-435.
  • Moseley GW, Elliott J, Wright MD, Partridge LJ & Monk PN (2003) . INT J CANCER, 105(5), 613-616.
  • Cesaro-Tadic S, Lagos D, Honegger A, Rickard JH, Partridge LJ, Blackburn GM & Pluckthun A (2003) . NAT BIOTECHNOL, 21(6), 679-685.
  • Behrendt M, Partridge LJ, Griffiths B, Goodfield M, Snaith M & Lindsey NJ (2003) . Clin Exp Immunol, 131(1), 182-189.
  • Carey JR, Liedo P, Harshman L, Zhang Y, M眉ller H-G, Partridge L & Wang J-L (2002) . Aging Cell, 1(2), 140-148.
  • Gems D, Pletcher S & Partridge L (2002) . Aging Cell, 1(1), 1-9.
  • Buckle C, Wells M & Partridge LJ (2002) Production of human monoclonal antibodies to an ovarian carcinoma-associated antigen (HPLAP) using phage display. J PATHOL, 198, 19A-19A.
  • Partridge L & Gems D (2002) . Nature, 418(6901), 921-921.
  • Betley JR, Cesaro-Tadic S, Mekhalfia A, Rickard JH, Denham H, Partridge LJ, Pl眉ckthun A & Blackburn GM (2002) . Angewandte Chemie - International Edition, 41(9), 1460.
  • Betley JR, Cesaro-Tadic S, Mekhalfia A, Rickard JH, Denham H, Partridge LJ, Pl眉ckthun A & Blackburn GM (2002) Direkte Identifizierung von Proteinkatalysatoren mit Phosphatase-Aktivit盲t durch kovalente Bindung an ein Suizid-Substrat. Angewandte Chemie, 114(5), 801-803.
  • Betley JR, Cesaro-Tadic S, Mekhalfia A, Rickard JH, Denham H, Partridge LJ, Pl眉ckthun A & Blackburn GM (2002) Direct screening for phosphatase activity by turnover-based capture of protein catalysts.. Angew Chem Int Ed Engl, 41(5), 775-777.
  • Gardner M, Fowler K, Partridge L & Barton N (2001) . Evolution, 55(8), 1609-1620.
  • Chapman T, Herndon LA, Heifetz Y, Partridge L & Wolfner MF (2001) . Proceedings of the Royal Society of London. Series B: Biological Sciences, 268(1477), 1647-1654.
  • Muranova TA, Ruzheinikov SN, Sedelnikova SE, Moir A, Partridge LJ, Kakinuma H, Takahashi N, Shimazaki K, Sun J, Nishi Y & Rice DW (2001) . Acta Crystallogr D Biol Crystallogr, 57(Pt 8), 1192-1195.
  • Sgro CM, Geddes G, Fowler K & Partridge L (2000) . Evolution, 54(6), 2152-2155.
  • Gilchrist AS & Partridge L (2000) . Evolution, 54(2), 534-542.
  • Yazici ZA, Behrendt M, Cooper D, Goodfield M, Partridge LJ & Lindsey NJ (2000) The identification of endothelial cell autoantigens. J AUTOIMMUN, 15(1), 41-49.
  • BARTON NH & PARTRIDGE L (2000) . Genetical Research, 75(3), 297-313.
  • Higginbottom A, Wilkinson I, McCullough B, Lanza F, Azorsa DO, Partridge LJ & Monk PN (2000) . Immunology, 99(4), 546-552.
  • Zwaan BJ, Azevedo RBR, James AC, van 't Land J & Partridge L (2000) . Heredity, 84(3), 338-347.
  • Sgro虁 CM & Partridge L (1999) . Science, 286(5449), 2521-2524.
  • Clayton R, Cooke ID, Partridge LJ & Moore HD (1998) . Biol Reprod, 59(5), 1180-1186.
  • Herndon LA, Chapman T, Kalb JM, Lewin S, Partridge L & Wolfner MF (1997) . Journal of Insect Physiology, 43(12), 1117-1123.
  • Gilchrist AS & Partridge L (1997) . Proceedings of the Royal Society of London. Series B: Biological Sciences, 264(1386), 1271-1275.
  • Azevedo RBR, French V & Partridge L (1997) . The American Naturalist, 150(2), 250-282.
  • McCabe J & Partridge L (1997) . Evolution, 51(4), 1164-1164.
  • Gilchrist GW, Huey RB & Partridge L (1997) . Physiological Zoology, 70(4), 403-414.
  • Yazici ZA, Beherendt M, Goodfield M, Partridge LJ & Lindsey NJ (1997) A human monoclonal antiendothelial cell autoantibody uses a V-H gene associated with an anti-DNA autoantibody.. BIOCHEM SOC T, 25(2), S321-S321.
  • Wentworth P, Datta A, Smith S, Marshall A, Partridge LJ & Blackburn GM (1997) Antibody catalysis of B(Ac)2 aryl carbamate ester hydrolysis: A highly disfavored chemical process. J AM CHEM SOC, 119(9), 2315-2316.
  • (1996) . Proceedings of the Royal Society of London. Series B: Biological Sciences, 263(1371), 755-759.
  • Blackburn GM, Datta A & Partridge LJ (1996) The medical potential of catalytic antibodies. PURE APPL CHEM, 68(11), 2009-2016.
  • Yazici ZA, Beherendt M, Goodfield M, Partridge LJ & Lindsey NJ (1996) A human monoclonal antiendothelial cell autoantibody uses a V-H gene associated an anti-DNA autoantibody. IMMUNOLOGY, 89, BB321-BB321.
  • McCullough B, Monk P, Morton I & Partridge L (1996) hCD63 binding by MAb's from the platelet workshop blind panel. TISSUE ANTIGENS, 48(4-II), PL105-PL105.
  • McCullough B, Monk P, Morton I & Partridge L (1996) Analysis of the reactivity of antibodies from the blind panel of the myeloid workshop with hCD63. TISSUE ANTIGENS, 48(4-II), MC505-MC505.
  • Wentworth P, DAtta A, Blakey D, Boyle T, Partridge LJ & Blackburn GM (1996) Toward antibody-directed ''abzyme'' prodrug therapy, ADAPT: Carbamate prodrug activation by a catalytic antibody and its in vitro application to human tumor cell killing. P NATL ACAD SCI USA, 93(2), 799-803.
  • Smith DA, Monk PN & Partridge LJ (1995) . Mol Immunol, 32(17-18), 1339-1344.
  • Monk PN, Barker MD, Partridge LJ & Pease JE (1995) . J Biol Chem, 270(28), 16625-16629.
  • RYAN GJ, MULCAHY KA, MORTON K & PARTRIDGE LJ (1995) CHARACTERIZATION OF NUCLEAR TRANSPORT-SYSTEM AND MOLECULES INVOLVED IN NUCLEAR-PROTEIN LOCALIZATION IN HUMAN MONONUCLEAR PHAGOCYTE CELL-LINES. J CELL BIOCHEM, 145-145.
  • Monk PN, Barker MD & Partridge LJ (1994) . Biochim Biophys Acta, 1221(3), 323-329.
  • MOIR AJG, MCKENZIE A, BUDDRUS S, REED M & PARTRIDGE LJ (1994) DIGESTION OF ACTIN WITH GLY-C AND THE LOCALIZATION OF THE EPITOPE FOR THE MONOCLONAL-ANTIBODY NH3. J MUSCLE RES CELL M, 15(2), 196-196.
  • PARTRIDGE LJ, SHEN JQ, DENG SX, HEATON A, BORRIELLO A, BURTON DR & BLACKBURN GM (1994) STRATEGIES FOR THE PRODUCTION OF CATALYTIC ANTIBODIES USING COMBINATORIAL LIBRARIES. J CELL BIOCHEM, 195-195.
  • HEXHAM JM, PARTRIDGE LJ, FURMANIAK J, PETERSEN VB, COLLS JC, PEGG CAS, SMITH BR & BURTON DR (1994) HUMAN THYROID AUTOANTIBODIES FROM PCOMB3 PHAGE DISPLAY COMBINATORIAL LIBRARIES. J CELL BIOCHEM, 200-200.
  • Partridge LJ (1994) . Methods Mol Biol, 27, 65-86.
  • Hexham JM, Partridge LJ, Furmaniak J, Petersen VB, Colls JC, Pegg C, Rees Smith B & Burton DR (1994) . Autoimmunity, 17(3), 167-179.
  • Shen J, Deng SX, Partridge LJ & Blackburn GM (1993) . Biochem Soc Trans, 21(4), 415S.
  • Monk PN & Partridge LJ (1993) . Biochem J, 295 ( Pt 3), 679-684.
  • Partridge LJ (1993) . Biochem Soc Trans, 21(4), 1096-1098.
  • WILLIAMSON RA, BURIONI R, SANNA PP, PARTRIDGE LJ, BARBAS CF & BURTON DR (1993) HUMAN MONOCLONAL-ANTIBODIES AGAINST A PLETHORA OF VIRAL PATHOGENS FROM SINGLE COMBINATORIAL LIBRARIES. P NATL ACAD SCI USA, 90(9), 4141-4145.
  • Santos M, Fowler K & Partridge L (1992) . Heredity, 69(6), 489-495.
  • Partridge L (1992) . Trends in Ecology & Evolution, 7(3), 99-100.
  • Partridge LJ, Dransfield I & Burton D (1990) . Biochem Soc Trans, 18(2), 274-275.
  • Divecha N, Mansouri H, Peat D, Cope G, Partridge L & McDonald CJ (1989) . J Mol Endocrinol, 3(1), 7-14.
  • Burton DR, Jefferis R, Partridge LJ & Woof JM (1988) . Mol Immunol, 25(11), 1175-1181.
  • DUNCAN AR, WOOF JM, PARTRIDGE LJ, BURTON DR & WINTER G (1988) LOCALIZATION OF THE BINDING-SITE FOR THE HUMAN HIGH-AFFINITY FC RECEPTOR ON IGG. NATURE, 332(6164), 563-564.
  • DRANSFIELD I, MOIR AJG, SHETH B, BURTON DR & PARTRIDGE LJ (1988) INITIAL CHARACTERIZATION OF AN ANTI-ACTIN MONOCLONAL-ANTIBODY (NH3). BIOCHEM SOC T, 16(2), 163-164.
  • Sheth B, Dransfield I, Partridge LJ, Barker MD & Burton DR (1988) Dibutyryl cyclic AMP stimulation of a monocyte-like cell line, U937: a model for monocyte chemotaxis and Fc receptor-related functions.. Immunology, 63(3), 483-490.
  • Dransfield I, Corcoran D, Partridge LJ, Hogg N & Burton DR (1988) Comparison of human monocytes isolated by elutriation and adherence suggests that heterogeneity may reflect a continuum of maturation/activation states.. Immunology, 63(3), 491-498.
  • ALFADHL DH, SHARRARD RM, PARTRIDGE LJ, BURTON DR, GALLAGHER JA, SHEARD CE, BOBROW L, PRINGLE JAS & RUSSELL RGG (1987) CHARACTERIZATION OF A MONOCLONAL-ANTIBODY (DA1) WHICH REACTS WITH BONE-MATRIX AND BONE CELL CYTOPLASM. BONE, 8(1), 46-46.
  • PARTRIDGE LJ, WOOF JM, JEFFERIS R & BURTON DR (1986) THE USE OF ANTI-IGG MONOCLONAL-ANTIBODIES IN MAPPING THE MONOCYTE RECEPTOR-SITE ON IGG. MOL IMMUNOL, 23(12), 1365-1372.
  • WOOF JM, PARTRIDGE LJ, JEFFERIS R & BURTON DR (1986) LOCALIZATION OF THE MONOCYTE-BINDING REGION ON HUMAN IMMUNOGLOBULIN-G. MOL IMMUNOL, 23(3), 319-330.
  • PARTRIDGE L, JEFFERIS R, HARDIE D, LING NR & RICHARDSON P (1984) SUBCLASSES OF IGG ON THE SURFACE OF HUMAN-LYMPHOCYTES - A STUDY WITH MONOCLONAL-ANTIBODIES. CLIN EXP IMMUNOL, 56(1), 167-174.
  • PARTRIDGE LJ, LOWE J, HARDIE DL, LING NR & JEFFERIS R (1982) IMMUNOGENIC AND ANTIGENIC EPITOPES OF IMMUNOGLOBULINS .2. ANTIGENIC DIFFERENCES BETWEEN SECRETED AND MEMBRANE IGG DEMONSTRATED USING MONOCLONAL-ANTIBODIES. J IMMUNOL, 128(1), 1-6.
  • Lennicke C, Bjedov I, Gr枚nke S, Menger KE, James AM, Castillo-Quan JI, van Leeuwen LAG, Foley A, Buricova M, Adcott J , Montoya A et al () . Nature Communications, 16(1).
  • Giblin A, Cammack AJ, Blomberg N, Anoar S, Mikheenko A, Carcol茅 M, Atilano ML, Hull A, Shen D, Wei X , Coneys R et al () . Nature Neuroscience.
  • Giblin A, Cammack AJ, Blomberg N, Anoar S, Mikheenko A, Carcol茅 M, Atilano ML, Hull A, Shen D, Wei X , Coneys R et al () . Nature Neuroscience.
  • Green LR, Issa R, Albaldi F, Urwin L, Thompson R, Khalid H, Turner CE, Ciani B, Partridge LJ & Monk PN () . mBio.
  • Ma J, Scott CA, Ho YN, Mahabaleshwar H, Marsay KS, Zhang C, Teow CKJ, Ng SS, Zhang W, Tergaonkar V , Partridge LJ et al () . eLife, 10.
  • Partridge LJ, Urwin L, Nicklin MJH, James DC, Green LR & Monk PN () . Cells, 10(6), 1419-1419.
  • Okurowska K, Roy S, Thokala P, Partridge L, Garg P, MacNeil S, Monk PN & Karunakaran E () . Journal of Visualized Experiments(159).
  • Rust A, Partridge L, Davletov B & Hautbergue G () . Toxins, 9(11), 344-344.
  • Sofola-Adesakin O, Castillo-Quan JI, Rallis C, Tain LS, Bjedov I, Rogers I, Li L, Martinez P, Khericha M, Cabecinha M , B脙陇hler JR et al () . Frontiers in Aging Neuroscience, 6.
  • Metaxakis A, Tain LS, Gr枚nke S, Hendrich O, Hinze Y, Birras U & Partridge L () . PLoS Biology, 12(4), e1001824-e1001824.
  • Selman C, Partridge L & Withers DJ () . PLoS ONE, 6(1), e16144-e16144.
  • Augustin H, Allen MJ & Partridge L () . Journal of Visualized Experiments(47).
  • Broughton S, Alic N, Slack C, Bass T, Ikeya T, Vinti G, Tommasi AM, Driege Y, Hafen E & Partridge L () . PLoS ONE, 3(11), e3721-e3721.
  • Piper MDW & Partridge L () . PLoS Genetics, 3(4), e57-e57.
  • Mair W, Piper MDW & Partridge L () . PLoS Biology, 3(7), e223-e223.

Conference proceedings

  • Hassuna N, Monk P, Read R & Partridge L (2010) The role of tetraspanin proteins in macrophage uptake of Salmonella bacteria. IMMUNOLOGY, Vol. 131 (pp 80-80)
  • Partridge LJ, Varadharajan P, Hulme R & Monk P (2008) Roles for tetraspanin proteins in the fusion of human monocytes to form multinucleated giant cells. IMMUNOLOGY, Vol. 125 (pp 6-7)
  • Scola AM, Higginbottom A, Partridge LJ & Monk PN (2007) . MOLECULAR IMMUNOLOGY, Vol. 44(1-3) (pp 237-237)
  • Blackburn GM, Rickard JH, Cesaro-Tadic S, Lagos D, Mekhalfia A, Partridge L & Pluckthun A (2004) Passive and catalytic antibodies and drug delivery. PURE AND APPLIED CHEMISTRY, Vol. 76(5) (pp 983-989)
  • Wong CH, Higginbottom A, Monk P, Partridge LJ & Moore HD (2001) Inhibition of sperm-oolemma interactions by the extracellular domains of CD9 and CD81. ANDROLOGY IN THE 21ST CENTURY, SHORT COMMUNICATIONS (pp 565-572)
  • Yazici ZA, Behrendt M, Goodfield M, Partridge LJ & Lindsey NJ (1998) Does the CDR3 of the heavy chain determine the specificity of autoantibodies in systemic lupus erythematosus?. JOURNAL OF AUTOIMMUNITY, Vol. 11(5) (pp 477-483)
  • McCullough B, Peppa D, Monk PN, Skubitz KM & Partridge LJ (1996) A role for CD63 in signal transduction. IMMUNOLOGY, Vol. 89 (pp OM114-OM114)
  • Higginbottom A, Partridge LJ & Monk PN (1996) Identification of potential ligands for CD63 from random peptide libraries. IMMUNOLOGY, Vol. 89 (pp OM117-OM117)

Preprints

  • Bustos V, McDonagh L, Digiacomo B, Meilenbrock RL, E脽er J, Gr枚nke S, Slack C & Partridge L (2025) , Cold Spring Harbor Laboratory.
  • Gkioni L, Nespital T, Monz贸 C, Bali J, Nassr T, Cremer AL, Beyer A, Backes H, Gr枚nke S & Partridge L (2024) , Cold Spring Harbor Laboratory.
  • Green LR, Issa R, Albaldi F, Urwin L, Khalid H, Turner CE, Ciani B, Partridge LJ & Monk PN (2023) , Cold Spring Harbor Laboratory.
  • Greaves S, Marsay KS, Monk PN, Roehl H & Partridge LJ () .
  • Marsay KS, Greaves S, Mahabaleshwar H, Ho CM, Roehl H, Monk PN, Carney TJ & Partridge LJ () .
  • Jiajia MA, Scott CA, Ying Na HO, Mahabaleshwar H, Marsay KS, Zhang C, Teow CKJ, Ser Sue NG, Zhang W, Tergaonkar V , Partridge LJ et al () , Cold Spring Harbor Laboratory.
  • Partridge LJ, Urwin L, Nicklin MJH, James DC, Green LR & Monk PN () .
Research group

Most of my current research is focussed on the role of tetraspanins in bacterial infections. Together with colleagues in Medicine and Engineering in Sheffield and at the LV-Prasad Eye Institute in Hyderabad, I am a co-investigator on an MRC GCRF-funded project that aims to develop new anti-adhesive treatments for infections that cause corneal ulceration and blindness. With colleagues in Medicine in Sheffield and Mahidol University in Bangkok, we have also been investigating the role of tetraspanins in the tropical disease melioidosis. I currently supervise three PhD students as primary supervisor and two as secondary supervisor.

Teaching activities

Level 4 modules

  • MBB405 Advanced Research Topics

Level 3 modules

  • MBB311 Molecular Immunology (Module Coordinator)

Level 2 modules

  • MBB263 Microbiology 2

Level 1 modules

  • MBB163 Microbiology
Professional activities and memberships

I am Chair of the Yorkshire Branch of Royal Society of Biology, represent the Sheffield region for the British Society of Immunology, and am a Fellow of the Royal Society of Biology.