Dr Emily No毛l

School of Biosciences

Senior Lecturer

British Heart Foundation Intermediate Basic Science Research Fellow, Emily No毛l
Profile picture of British Heart Foundation Intermediate Basic Science Research Fellow, Emily No毛l
e.s.noel@sheffield.ac.uk
C21, Firth Court

Full contact details

Dr Emily No毛l
School of Biosciences
C21
Firth Court
Western Bank
Sheffield
S10 2TN
Profile

Brief career history

  • 2017-Present: British Heart Foundation Intermediate Basic Science Research Fellow, 爆料TV, UK
  • 2015-2017: Independent Research Fellow, 爆料TV, UK
  • 2009-2015: Postdoctoral Research Scientist, Bakkers Lab, Hubrecht Institute, Utrecht, NL
  • 2005-2009: PhD Student, Ober Lab, National Institute for Medical Research, London, UK
  • 2001-2004: BSc Biochemistry, University of Warwick
Research interests

The heart is a highly complex organ that forms very early during embryonic development from a simple linear tube. Problems with heart development often result in babies being born with congenital heart defects, a spectrum of structural heart malformations which affect around 1% of live births. Studying how hearts form when an organism is developing helps us better understand why this process sometimes goes wrong.

Our lab uses zebrafish to understand how the developing heart undergoes complex morphological rearrangements. We are particularly interested in how cells interact with their cellular neighbours or the extracellular matrix in different regions of the heart, and how these regionalised interactions support heart form and function as the embryo develops.

We use a variety of genetic and imaging techniques in zebrafish to link cellular processes/signalling, extracellular matrix composition, and heart morphology and function. These include establishing genetic models through targeted gene editing using CRISPR-Cas9, live light-sheet imaging of transgenic lines with fluorescent tissues or reporters, and quantitative image analyses.

Publications

Show: Featured publications All publications

Journal articles

  • Bowley G, Kugler E, Wilkinson R, Lawrie A, Eeden F, Chico TJA, Evans PC, No毛l ES & Serbanovic鈥怌anic J (2022) . British Journal of Pharmacology, 179(5), 900-917.
  • Derrick CJ, S谩nchez-Posada J, Hussein F, Tessadori F, Pollitt EJG, Savage AM, Wilkinson RN, Chico TJ, van Eeden FJ, Bakkers J & No毛l ES (2022) . Cardiovascular Research, 118(1), 226-240.
  • Derrick CJ, Pollitt EJG, Sevilla Uruchurtu AS, Hussein F, Grierson AJ & No毛l ES (2021) . Development, 148(20).
  • Derrick CJ & No毛l ES (2021) . Development, 148(5).
  • No毛l ES, Momenah TS, Al-Dagriri K, Al-Suwaid A, Al-Shahrani S, Jiang H, Willekers S, Oostveen YY, Chocron S, Postma AV , Bhuiyan ZA et al (2016) . Human Mutation, 37(2), 194-200.
  • Junker JP, No毛l ES, Guryev V, Peterson KA, Shah G, Huisken J, McMahon AP, Berezikov E, Bakkers J & van聽Oudenaarden A (2014) . Cell, 159(3), 662-675.
  • Smith KA, Noel E, Thurlings I, Rehmann H, Chocron S & Bakkers J (2011) . PLoS Genetics, 7(9).
  • No毛l ES & Bakkers J () . eLife, 6.
  • No毛l ES, Verhoeven M, Lagendijk AK, Tessadori F, Smith K, Choorapoikayil S, den Hertog J & Bakkers J () . Nature Communications, 4(1).

All publications

Journal articles

  • S谩nchez-Posada J, Derrick CJ & No毛l ES (2025) . PLOS Biology, 23(1).
  • Bowley G, Irving S, Hoefer I, Wilkinson R, Pasterkamp G, Darwish HMS, White S, Francis SE, Chico T, Noel E , Serbanovic-Canic J et al (2024) . Scientific Reports, 14(1).
  • Pollitt EJG, S谩nchez-Posada J, Snashall CM, Derrick CJ & No毛l ES (2024) . Development, 151(13).
  • Bowley G, Kugler E, Wilkinson R, Lawrie A, Eeden F, Chico TJA, Evans PC, No毛l ES & Serbanovic鈥怌anic J (2022) . British Journal of Pharmacology, 179(5), 900-917.
  • Derrick CJ, S谩nchez-Posada J, Hussein F, Tessadori F, Pollitt EJG, Savage AM, Wilkinson RN, Chico TJ, van Eeden FJ, Bakkers J & No毛l ES (2022) . Cardiovascular Research, 118(1), 226-240.
  • Derrick CJ, Pollitt EJG, Sevilla Uruchurtu AS, Hussein F, Grierson AJ & No毛l ES (2021) . Development, 148(20).
  • Derrick CJ & No毛l ES (2021) . Development, 148(5).
  • Campbell K, No毛l ES, Fletcher AG & Bulgakova NA (2020) . Philosophical Transactions of the Royal Society B: Biological Sciences, 375(1809).
  • Han MK, Hoijman E, N枚el E, Garric L, Bakkers J & de Rooij J (2016) . Biology Open, 2016(5), 1461-1472.
  • No毛l ES, Momenah TS, Al-Dagriri K, Al-Suwaid A, Al-Shahrani S, Jiang H, Willekers S, Oostveen YY, Chocron S, Postma AV , Bhuiyan ZA et al (2016) . Human Mutation, 37(2), 194-200.
  • Wu C-C, Kruse F, Vasudevarao MD, Junker JP, Zebrowski DC, Fischer K, No毛l ES, Gr眉n D, Berezikov E, Engel FB , van聽Oudenaarden A et al (2016) . Developmental Cell, 36(1), 36-49.
  • Tessadori F, No毛l ES, Rens EG, Magliozzi R, Evers-van聽Gogh IJA, Guardavaccaro D, Merks RMH & Bakkers J (2015) . Developmental Cell, 32(5), 631-639.
  • Junker JP, No毛l ES, Guryev V, Peterson KA, Shah G, Huisken J, McMahon AP, Berezikov E, Bakkers J & van聽Oudenaarden A (2014) . Cell, 159(3), 662-675.
  • Bonetti M, Paardekooper Overman J, Tessadori F, No毛l E, Bakkers J & den Hertog J (2014) . Development, 141(9), 1961-1970.
  • Smith KA, Noel E, Thurlings I, Rehmann H, Chocron S & Bakkers J (2011) . PLoS Genetics, 7(9).
  • Mas JC, No毛l ES & Ober EA (2011) , 401-428.
  • No毛l ES, Reis MD, Arain Z & Ober EA (2010) . Gene Expression Patterns, 10(6), 237-243.
  • No毛l ES, Casal-Sueiro A, Busch-Nentwich E, Verkade H, Dong PDS, Stemple DL & Ober EA (2008) . Developmental Biology, 322(2), 237-250.
  • No毛l ES & Bakkers J () . eLife, 6.
  • No毛l ES, Verhoeven M, Lagendijk AK, Tessadori F, Smith K, Choorapoikayil S, den Hertog J & Bakkers J () . Nature Communications, 4(1).

Book chapters

  • No毛l ES (2024) , Current Topics in Developmental Biology (pp. 121-156). Elsevier

Conference proceedings

  • Sanchez-Posada J & Noel ES (2022) morphoHeart: A novel tool to capture, quantify and link 3D asymmetric heart morphogenesis with spatiotemporal extracellular matrix dynamics in zebrafish cardiac development. JOURNAL OF ANATOMY, Vol. 240(4) (pp 785-786)
  • Derrick CJ, Hussein F, Pollitt EJG & Noel ES (2021) Laminins regulate cardiac growth through restricting second heart field addition. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 102(2) (pp 126-126)
  • Carr PL, Jiang Z, Savage AM, No毛l ES, Wilkinson RN & Lawrie A (2019) . C49. TICKET TO RIDE: EXPERIMENTAL MODELS OF PAH (pp A5038-A5038)

Preprints

  • Jin Jie CC, Santos-Oliv谩n D, Ramel M-C, S谩nchez-Posada J, Andrews TGR, Paizakis P, No毛l ES, Torres-S谩nchez A & Priya R (2025) , Cold Spring Harbor Laboratory.
  • Pollitt EJG, Derrick CJ, S谩nchez-Posada J & No毛l ES (2023) , Cold Spring Harbor Laboratory.
  • Derrick CJ, Pollitt EJG, Uruchurtu ASS, Hussein F & No褢l ES (2021) , Cold Spring Harbor Laboratory.
  • Derrick CJ, S谩nchez-Posada J, Hussein F, Tessadori F, Pollitt EJG, Savage AM, Wilkinson RN, Chico TJ, van Eeden FJ, Bakkers J & No毛l ES (2019) , Cold Spring Harbor Laboratory.
Research group
Grants
  • British Heart Foundation
  • Academy of Medical Sciences/Wellcome Trust
  • Rosetrees Trust
Teaching activities
  • BMS110 Research Topics in Biomedicine
  • BMS242/3 Advanced Concepts in Developmental Biology
  • BMS356 Biomedical Technology & Drug Discovery
  • BMS336 Modelling Human Disease
  • BMS397 Laboratory Research Project
  • L4/MSc Dissertation and Laboratory Research Supervision

Links